Organized into three sections encompassing 21 chapters, this volume begins with an overview of the history of rabies as well as its morphology and morphogenesis. It then discusses the virus' antigenic composition and relationships, hemagglutinin and the optimal conditions for its preparation and demonstration, advantages and disadvantages of the passive hemagglutination test, methods for concentration and purification of the virus, and growth in cell culture. It explains the virus' pathogenesis to and spread within and from the CNS, electron microscopy of CNS and extraneural rabies infection, lipotropism in rabies virus infection, use of exogenous and endogenous interferon to inhibit rabies virus infection, mouse inoculation and Negri body diagnosis, and fluorescent antibody test in rabies. The book concludes with an assessment of the serum neutralization, indirect fluorescent antibody, and rapid fluorescent focus inhibition tests.
This book is a valuable resource for virologists, pathologists, epidemiologists, and students.
The book begins with a history of virology, tracing the development of knowledge and research on virology. The remaining seven chapters deal with the function and formation of virus particles; the structure and complexity of virus genomes; virus replication; gene expression; virus infections; the effects of virus infection on the body and the body’s response to infection; and subviral agents, such as satellites, viroids, and prions. The text concludes with three appendices that feature a glossary and abbreviations; a classification of subcellular infectious agents; and an outline of the history of virology.Completely rewritten and updatedClear and easy to understandExamples covering important ideas in virologyAll new illustrations
Molecular Virology of Human Pathogenic Virusesprovides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature.Presents viruses within their family structureContains recommended journal articles with perspectives to put primary literature in contextIncludes integrated recommended reading references within each chapterProvides access to online ancillary package inclusive of annotated PowerPoint images, instructor’s manual, study guide, and test bank
The next big human pandemic—the next disease cataclysm, perhaps on the scale of AIDS or the 1918 influenza—is likely to be caused by a new virus coming to humans from wildlife. Experts call such an event “spillover” and they warn us to brace ourselves. David Quammen has tracked this subject from the jungles of Central Africa, the rooftops of Bangladesh, and the caves of southern China to the laboratories where researchers work in space suits to study lethal viruses. He illuminates the dynamics of Ebola, SARS, bird flu, Lyme disease, and other emerging threats and tells the story of AIDS and its origins as it has never before been told. Spillover reads like a mystery tale, full of mayhem and clues and questions. When the Next Big One arrives, what will it look like? From which innocent host animal will it emerge? Will we be ready?