Diseases of the Nervous System

Academic Press
Free sample

The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles.

Diseases of the Nervous System summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine.

This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system.

  • 2016 PROSE Award winner of the Best Textbook Award in Biological & Life Sciences
  • Provides a focused tutorial introduction to the core diseases of the nervous system
  • Includes comprehensive introductions to Stroke, Epilepsy, Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease, ALS, Head and Spinal Cord Trauma, Multiple Sclerosis, Brain Tumors, Depression, Schizophrenia and many other diseases of the nervous system
  • Covers more than 40 diseases from the foundational science to the best treatment protocols
  • Includes discussions of translational research, drug discovery, personalized medicine, ethics, and neuroscience
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About the author

Dr. Sontheimer is a researcher and educator with a life-long interest in Neuroscience. A native of Germany, he obtained a Masters degree in evolutionary comparative Neuroscience, where he worked on the development of occulomotor reflexes. In 1989, he obtained a doctorate in Biophysics and Cellular & Molecular Neuroscience form the University of Heidelberg studying biophysical changes that accompany the development of oligodendrocytes, the principle myelinating cells of the nervous system. He moved to the United States, where he later became a citizen, for post-doctoral studies at Yale University. His independent research career began at Yale in 1991 and continued at the University of Alabama Birmingham from 1994-2015, and, more recently at Virginia Tech. His research focuses on the role of glial support cells in health and disease. His laboratory has made major discoveries that led to two clinical trials using novel compounds to treat malignant gliomas. His research led to over 170 peer-reviewed publications. For the clinical development of his discoveries, Dr. Sontheimer started a biotechnologies company, Transmolecular Inc., which conducted both phase I and II clinical trials with the anti-cancer agent chlorotoxin. This technology was recently acquired by Morphotec Pharmaceuticals, who will be conducting the phase III clinical trials. As educator, Dr. Sontheimer has been active in teaching Medical Neuroscience, graduate Cellular and Molecular Neuroscience, and, for the past 10 years, he has offered both graduate and undergraduate courses on Diseases of the Nervous System. In 2005, Dr. Sontheimer became director of the Civitan International Research Center, a philanthropically supported center in Birmingham AL devoted to the study and treatment of children with developmental disabilities, ranging from Down’s syndrome to Autism. In this capacity, Dr. Sontheimer was frequently tasked explaining complex scientific processes to a lay audience. Recognizing the need to further educate the public about neurological disorders using language that is accessible to an educated public motivated Dr. Sontheimer to write a textbook on Diseases of the Nervous system. To assure that the material is comprehensive yet readily understandable, he wrote large parts of this text while on sabbatical leave at Rhodes College in Memphis, where he taught undergraduates while testing his book on this group of talented third and fourth year Neuroscience students. In 2015 Dr. Sontheimer was tapped to found a School of Neuroscience at Virginia Tech with the goal to offer a unique Neuroscience education to an increasing number of undergraduates. As the first of its kind, this enterprise will ultimately represent an entire college dedicated to a variety of Neuroscience experiences and include majors in clinical, experimental, cognitive, systems, computational and social Neuroscience. Enrollment is expected to exceed 1000 undergraduate students. Dr. Sontheimer continues to manage a very active research laboratory at the Virginia Tech Carilion Research Institute where he involves a spectrum of trainees ranging from undergraduates to post-doctoral scientists. Dr. Sontheimer has already trained well over 50 Ph.D. students and post-doctoral fellows.

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Additional Information

Publisher
Academic Press
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Published on
Mar 6, 2015
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Pages
520
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ISBN
9780128004036
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Language
English
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Genres
Medical / Neurology
Science / Life Sciences / Neuroscience
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Content Protection
This content is DRM protected.
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Available on Android devices
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Eligible for Family Library

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Conn’s Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes.

This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis.

In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn’s Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.

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Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders provides a new and unifying methodological framework, introducing new objective biometrics to characterize patterns of sensory motor control underlying symptoms. Its goal is to radically transform the ways in which disorders of the nervous system are currently diagnosed, tracked, researched and treated. This book introduces new ways to bring the laboratory to the clinical setting, to schools and to settings of occupational and physical therapy. Ready-to-use, graphic user interfaces are introduced to provide outcome measures from wearable sensors that automatically assess in near real time the effectiveness of interventions. Lastly, examples of how the new framework has been effectively utilized in the context of clinical trials are provided. Provides methods and their implementation using real data and simple computer programs that students and researchers from less technically trained fields can useDescribes the motivation for methods according to the problem domain in light of existing methods for each chapter, along with their lack of neuroscientific foundation and invalid statistical assumptionsAccompanied by a companion website which contains Appendices with MATLAB codes and data samples to generate the graphics displayed in all chapter figuresFeatures videos illustrating the experimental set up for scenarios and methods described in each chapterIncludes step-by-step explanations of paradigms in each clinical or typical sample population to enable reproducibility of the study across different clinical phenotypes and levels of expertise in sports, the performing arts, or mere individual academic predispositions/preferences
The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord.

The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders.

* Presents the evolution of the field of neurology into a therapeutic discipline
* Discusses lessons learned from past successes and applications to ongoing work
* Explores the future of this field
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