Understanding NMR Spectroscopy: Edition 2

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This text is aimed at people who have some familiarity withhigh-resolution NMR and who wish to deepen their understanding ofhow NMR experiments actually ‘work’. This revised andupdated edition takes the same approach as the highly-acclaimedfirst edition. The text concentrates on the description ofcommonly-used experiments and explains in detail the theory behindhow such experiments work. The quantum mechanical tools needed toanalyse pulse sequences are introduced set by step, but theapproach is relatively informal with the emphasis on obtaining agood understanding of how the experiments actually work. The use oftwo-colour printing and a new larger format improves thereadability of the text. In addition, a number of new topics havebeen introduced:
  • How product operators can be extended to describe experimentsin AX2 and AX3 spin systems, thus making it possible to discuss theimportant APT, INEPT and DEPT experiments often used in carbon-13NMR.
  • Spin system analysis i.e. how shifts and couplings can beextracted from strongly-coupled (second-order) spectra.
  • How the presence of chemically equivalent spins leads tospectral features which are somewhat unusual and possiblymisleading, even at high magnetic fields.
  • A discussion of chemical exchange effects has been introducedin order to help with the explanation of transverserelaxation.
  • The double-quantum spectroscopy of a three-spin system is nowconsidered in more detail.

Reviews of the First Edition

“For anyone wishing to know what really goes on in theirNMR experiments, I would highly recommend this book” –Chemistry World

“…I warmly recommend for budding NMRspectroscopists, or others who wish to deepen their understandingof elementary NMR theory or theoretical tools” –Magnetic Resonance in Chemistry

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About the author

Dr James Keeler is a Senior Lecturer in Chemistry at the University of Cambridge, and a Fellow of Selwyn College. In addition to being actively involved in the development of new NMR techniques, he is also responsible for the undergraduate chemistry course, and is Editor-In-chief of Magnetic Resonance in Chemistry. Dr Keeler is well-known for his clear and accessible exposition of NMR spectroscopy.
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Additional Information

Publisher
John Wiley & Sons
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Published on
Sep 19, 2011
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Pages
526
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ISBN
9781119964933
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Language
English
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Genres
Science / Chemistry / General
Science / Spectroscopy & Spectrum Analysis
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Content Protection
This content is DRM protected.
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Spin Dynamics: Basics of Nuclear Magnetic Resonance, SecondEdition is a comprehensive and modern introduction whichfocuses on those essential principles and concepts needed for athorough understanding of the subject, rather than the practicalaspects. The quantum theory of nuclear magnets is presented withina strong physical framework, supported by figures. 

The book assumes only a basic knowledge of complex numbers andmatrices, and provides the reader with numerous worked examples andexercises to encourage understanding. With the explicit aim ofcarefully developing the subject from the beginning, the textstarts with coverage of quarks and nucleons and progresses throughto a detailed explanation of several important NMR experiments,including NMR imaging, COSY, NOESY and TROSY. 

Completely revised and updated, the Second Edition features newmaterial on the properties and distributions of isotopes, chemicalshift anisotropy and quadrupolar interactions, Pake patterns, spinechoes, slice selection in NMR imaging, and a complete new chapteron the NMR spectroscopy of quadrupolar nuclei. New appendices havebeen included on Euler angles, and coherence selection by fieldgradients. As in the first edition, all material is heavilysupported by graphics, much of which is new to thisedition. 

Written for undergraduates and postgraduate students taking afirst course in NMR spectroscopy and for those needing anup-to-date account of the subject, this multi-disciplinary bookwill appeal to chemical, physical, material, life, medical, earthand environmental scientists. The detailed physical insights willalso make the book of interest for experienced spectroscopists andNMR researchers. 

• An accessible and carefully written introduction,designed to help students to fully understand this complex anddynamic subject

• Takes a multi-disciplinary approach, focusing on basicprinciples and concepts rather than the more practical aspects

• Presents a strong pedagogical approach throughout, withemphasis placed on individual spins to aid understanding

• Includes numerous worked examples, problems, furtherreading and additional notes

Praise from the reviews of the First Edition:

"This is an excellent book... that many teachers of NMRspectroscopy will cherish... It deserves to be a‘classic’ among NMR spectroscopy texts." NMRIN BIOMEDICINE

"I strongly recommend this book to everyone…it isprobably the best modern comprehensive description of thesubject." ANGEWANDTE CHEMIE, INTERNATIONAL EDITION

The derivation of structural information from spectroscopic datais now an integral part of organic chemistry courses at allUniversities.  A critical part of any such course is asuitable set of problems to develop the student’sunderstanding of how structures are determined fromspectra. 

Organic Structures from Spectra, Fifth Edition is acarefully chosen set of more than 280 structural problems employingthe major modern spectroscopic techniques, a selection of 27problems using 2D-NMR spectroscopy, more than 20 problemsspecifically dealing with the interpretation of spin-spin couplingin proton NMR spectra and 8 problems based on the quantitativeanalysis of mixtures using proton and carbon NMRspectroscopy.  All of the problems are graded to develop andconsolidate the student’s understanding of organicspectroscopy.  The accompanying text is descriptive and onlyexplains the underlying theory at a level which is sufficient totackle the problems.  The text includes condensed tables ofcharacteristic spectral properties covering the frequentlyencountered functional groups.

The examples themselves have been selected to include allimportant common structural features found in organic compounds andto emphasise connectivity arguments.  Many of the compoundswere synthesised specifically for this purpose.  There aremany more easy problems, to build confidence and demonstrate basicprinciples, than in other collections. 

The fifth edition of this popular textbook:

• includes more than 250 new spectra and more than 25completely new problems;
• now incorporates an expanded suite of new problemsdealing with the analysis of 2D NMR spectra (COSY, C H Correlationspectroscopy, HMBC, NOESY and TOCSY); 
• has been expanded and updated to reflect the newdevelopments in NMR and to retire older techniques that are nolonger in common use;
• provides a set of problems dealing specifically withthe quantitative analysis of mixtures using NMR spectroscopy;
• features proton NMR spectra obtained at 200, 400 and600 MHz and 13C NMR spectra include DEPT experiments as well asproton-coupled experiments;
• contains 6 problems in the style of the experimentalsection of a research paper and two examples of fully workedsolutions.

Organic Structures from Spectra, Fifth Edition will proveinvaluable for students of Chemistry, Pharmacy and Biochemistrytaking a first course in Organic Chemistry.

Contents
Preface 
Introduction 
Ultraviolet Spectroscopy 
Infrared Spectroscopy
Mass Spectrometry 
Nuclear Magnetic Resonance Spectroscopy 
2DNMR
Problems 
Index

Reviews from earlier editions

“Your book is becoming one of the “go to”books for teaching structure determination here in theStates.  Great work!”

“…I would definitely state that this book is themost useful aid to basic organic spectroscopy teaching in existenceand I would strongly recommend every instructor in this area to useit either as a source of examples or as a classtextbook”.
Magnetic Resonance in Chemistry

“Over the past year I have trained many students usingproblems in your book - they initially find it as a task.  Butafter doing 3-4 problems with all their brains activities...working out the rest of the problems become a mania.  They getaddicted to the problem solving and every time they solve a problemby themselves, their confident level also increases.”

 “I am teaching the fundamentals of MolecularSpectroscopy and your books represent excellent sources ofspectroscopic problems for students.”

Protein NMR Spectroscopy, Second Edition combines a comprehensive theoretical treatment of NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules in solution.

Beginning with simple theoretical models and experimental techniques, the book develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments.

Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. This updated version includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced.

The book is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or wish to understand the latest developments in this field.

Provides an understanding of the theoretical principles important for biological NMR spectroscopyDemonstrates how to implement, optimize and troubleshoot modern multi-dimensional NMR experimentsAllows for the capability of designing effective experimental protocols for investigations of protein structures and dynamicsIncludes a comprehensive set of example NMR spectra of ubiquitin provides a reference for validation of experimental methods
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