New in the Second Edition:
Tried-and-True Format Presents Updated Information
Keeping the same format that made the first edition so popular, the text begins with coverage of the basic principles underpinning the environmental behavior and effects of organic pollutants. It then describes the properties and ecotoxicology of major pollutants, discusses some issues that arise after consideration of the material in the second part of the text, and explores future prospects.
Mechanistic Approach Provides Basis for Development of New Strategies
The book takes a bottom up approach, describing the mechanisms by which pollutants have harmful effects on living organisms and how these effects are translated into adverse changes at the population level. This mechanistic approach supplies the basis for development of new mechanistic biomarker assays, which in turn provide measures of toxic effect and not merely of exposure, and subsequently provide evidence of causality between pollutant levels and ecological changes.
The book focuses on the following issues:
Uncertainties in the process of model development, such as design, analysis, documentation, and communication The availability of data and background information needed for optimal modeling The limited knowledge of modeling The lack of confidence in the outcome of ecological models and their reliability in pesticide risk assessment
It also suggests future solutions to these challenges, including:
A guidance document on the modeling process Case studies that show how ecological models can provide reliable ecologically relevant risk assessments Training the people who generate or evaluate results obtained by ecological models
Focusing on ecological models, such as unstructured population models, stage-structured matrix models, and individual- or agent-based models, this volume helps regulatory authorities, manufacturers, and scientists assess the risk of plant protection products in nontarget organisms. Armed with this knowledge, readers will better understand the challenges of using ecological modeling in the regulatory process.
Linking Aquatic Exposure and Effects: Risk Assessment of Pesticides provides guidance and recommendations for linking aquatic exposure and ecotoxicological effects in the environmental assessment of agricultural pesticides. Leading international scientists share their expertise in aquatic exposure assessment, aquatic ecotoxicology, and the risk assessment and management of plant protection products. The book incorporates the tools and approaches currently available for assessing the environmental risks of time-variable exposure profiles of pesticides. It also discusses the science behind these techniques.
This volume covers the extrapolation techniques, including models that address the environmental fate, toxicokinetics, toxicodynamics, and ecological effects, for performing accurate aquatic environmental risk assessments of pesticides. It explains how to link aquatic exposure and effects in the risk assessment procedure for plant protection products.
The book delineates the state of the science of the ecotoxicology of explosives, past, present, and recently developed. It reviews the accessible fate and ecotoxicological data for energetic materials (EMs) and the methods for their development. The chapters characterize the fate of explosives in the environment, then provide information on their ecological effects in key environmental media, including aquatic, sedimentary, and terrestrial habitats. The book also discusses approaches for assembling these lines of evidence for risk assessment purposes. The chapter authors have critically examined the peer-reviewed literature to identify and prioritize the knowledge gaps and to recommend future areas of research.
The editors include a review of the genotoxic effects of the EMs and the cellular and molecular mechanisms underlying the toxicity of these chemicals. They also discuss the transport, transformation, and degradation pathways of these chemicals in the environment that underlie the potential hazardous impact and bioaccumulation of EMs in different terrestrial and aquatic ecologiocal receptors. This information translates into practical applications for the environmental risk assessment of EM-contaminated sites and into recommendations for the sustainable use of defense installations.
This award, first established in 1962 by the Association of Environmental and Engineering Geologists, is named in honor of Claire P. Holdredge, a founding member and the first President of the Association. The award is presented for a publication by an AEG Member(s) within the 5 previous years that is adjudged to be an outstanding contribution to the Engineering Geology profession.
Remediation of Former Manufactured Gas Plants and Other Coal-Tar Sites is geared toward environmental professionals who want to design and implement gasworks remediation strategies that offer the greatest chance to successfully protect the public. Exploring the bases for selecting remedial alternatives to adequately address today’s environmental wounds, this compendium of essential knowledge combines historic and modern scientific data and technology with common sense and empirical lore passed down from past generations of gas professionals, a group that is now all but extinct.
Most of the general population does not have a sufficient understanding of remediation needs. Unfortunately, there seems to be a similar lack of knowledge among some environmental professionals whose job it is to protect the public from the health threats associated with coal tar. Pitfalls in remediation are common and represent a significant risk to the public, especially when processes are based on inaccurate assumptions.
This book sifts through the existing scholarship from around the developed world to present the necessary evaluation factors used in effective remediation. Almost encyclopedic in scope, it offers 265 separate tables with checklists, hard data facts, and associations to help readers define site-specific gas plant conditions. It also includes a plethora of photographs and historic drawings, as well as an extensive glossary that is indispensible for understanding potential and actual gas plant contamination.
Useful for engineers, scientists, regulators, public officials, historians, and journalists among others, this book is intended for those who conduct remediation, as well as those involved in review and oversight. Its goal is to bring users closer to safely reclaiming land and reviving old coal gasworks sites in ways that ultimately will be sustainable for the public interest.
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Knowledge flow provides learning book of Toxicology. This book is for all medical and science students, teachers and professionals across the world. To understanding, better key concepts of toxicology then this book of toxicology is very helpful with effective illustrations.
1. Introduction of Toxicology
2. Factors modifying drug action and dosage
3. Drug interactions
6. Drugs acting on cardiovascular system
7. Drugs acting on Gastrointestinal Tract
8. Antiviral drugs
9. Antimalarial drugs
10. Drugs for Tuberculosis
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• Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs
• Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective
• Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines
• Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan
• Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain