The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The second volume, Biomedical Diagnostics, focuses on biomedical diagnostic technologies and their applications from the bench to the bedside.
Represents the Collective Work of over 150 Scientists, Engineers, and Clinicians
Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies.
What’s New in This Edition:
A wide variety of photonic biochemical sensing technologies have already been developed for clinical monitoring of physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics and metabolomics allow sensing of early disease state biomarkers, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single cell level. In addition to these state-of-the art advancements, the second edition contains new topics and chapters including:
• Fiber Optic Probe Design
• Laser and Optical Radiation Safety
• Photothermal Detection
• Multidimensional Fluorescence Imaging
• Surface Plasmon Resonance Imaging
• Molecular Contrast Optical Coherence Tomography
• Multiscale Photoacoustics
• Polarized Light for Medical Diagnostics
• Quantitative Diffuse Reflectance Imaging
• Interferometric Light Scattering
• Nonlinear Interferometric Vibrational Imaging
• Multimodality Theranostics Nanoplatforms
• Nanoscintillator-Based Therapy
• SERS Molecular Sentinel Nanoprobes
• Plasmonic Coupling Interference Nanoprobes
Comprised of three books: Volume I: Fundamentals, Devices, and Techniques; Volume II: Biomedical Diagnostics; and Volume III: Therapeutics and Advanced Biophotonics, this second edition contains eight sections, and provides introductory material in each chapter. It also includes an overview of the topic, an extensive collection of spectroscopic data, and lists of references for further reading.
This handbook is the first to be entirely devoted to FF-OCM. It is organized into four parts with a total of 21 chapters written by recognized experts and major contributors to the field. After a general introduction to FF-OCM, the fundamental characteristics of the technology are analyzed and discussed theoretically. The main technological developments of FF-OCM for improving the image acquisition speed and for endoscopic imaging are presented in part II. Extensions of FF-OCM for image contrast enhancement or functional imaging are reported in part III. The last part of the book provides an overview of possible applications of FF-OCM in medicine, biology, and materials science.
A comprehensive compilation of self-contained chapters written by leading experts, this handbook is a definitive guide to the theoretical analyses, technological developments, and applications of FF-OCM. Using the rich information the book is replete with, a wide range of readers, from scientists and physicists to engineers as well as clinicians and biomedical researchers, can get a handle on the latest major advances in FF-OCM.
Organized into six sections, this handbook:
Contains introductory material on optics and the optical properties of tissue Describes the various forms of spectroscopy and its applications in medicine and biology, including methods that exploit intrinsic absorption and scattering contrast; dynamic contrast; and fluorescence and Raman contrast mechanisms Provides extensive coverage of tomography from the microscopic (optical coherence tomography) to the macroscopic (diffuse optical tomography) to photoacoustic tomography Discusses cutting-edge translations to biomedical applications in both basic sciences and clinical studies Details molecular imaging and molecular probe development Highlights the use of light in disease and injury treatment
The breadth and depth of multidisciplinary knowledge in biomedical optics has been expanding continuously and exponentially, thus underscoring the lack of a single source to serve as a reference and teaching tool for scientists in related fields. Handbook of Biomedical Optics addresses this need, offering the most complete up-to-date overview of the field for researchers and students alike.