Advanced Optical Flow Cytometry: Methods and Disease Diagnoses

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A detailed look at the latest research in non-invasive in vivo cytometry and its applications, with particular emphasis on novel biophotonic methods, disease diagnosis, and monitoring of disease treatment at single cell level in stationary and flow conditions.
This book thus covers the spectrum ranging from fundamental interactions between light, cells, vascular tissue, and cell labeling particles, to strategies and opportunities for preclinical and clinical research. General topics include light scattering by cells, fast video microscopy, polarization, laser-scanning, fluorescence, Raman, multi-photon, photothermal, and photoacoustic methods for cellular diagnostics and monitoring of disease treatment in living organisms. Also presented are discussions of advanced methods and techniques of classical flow cytometry.
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About the author

Valery Tuchin is Head of Chair of Optics and Biomedical Physics and Director of Research-Educational Institute of Optics and Biophotonics at Saratov State University. He has authored more than 250 papers and books, including his latest, Tissue Optics. Light Scattering Methods and Instrumentation for Medical Diagnosis (SPIE Tutorial Texts in Optical Engineering, Vol. TT38, 2000; second edition, PM166, 2007), Handbook of Optical Biomedical Diagnostics (SPIE Press, Vol. PM107, 2002), Coherent-Domain Optical Methods for Biomedical Diagnostics, Environmental and Material Science, Kluwer Academic Publishers, Boston, USA, vols. 1 & 2, 2004, Optical Clearing of Tissues and Blood (SPIE Press, Vol. PM154, 2005), and Optical Polarization in Biomedical Applications (co-authors L. Wang and D.A. Zimnyakov; Springer, 2006).

Some of the contributors:
Martin Leahy, University of Limerick, Ireland
Attila Tarnok, University of Leipzig, Germany
Andreas O.H. Gerstner, University of Bonn, Germany
Anja Mittag, University of Leipzig, Germany
Megha Makam, Daisy Diaz, Rabindra Tirouvanziam,
Stanford University School of Medicine, USA
Steven Boutrus, Derrick Hwu & Cherry Greiner, Tufts University, MA, USA
Michael Chan & Charlotte Kuperwasser, Tufts-New England Medical Center, MA, USA
Charles P. Lin & Irene Georgakoudi, Harvard Medical School,MA, USA
E.I. Galanzha, Saratov State University, Russia
V.P. Zharov, Arkansas University of Medical Science, USA
A.V. Priezzhev, A.G. Lugovtsov, S.Yu. Nikitin & Yu.I. Gurfinkel, Moscow State University, Russia
Valeri P. Maltsev, Maxim A. Yurkin & Elena Eremina,Institute of Chemical Kinetics and Combustion, Novosibirsk, Russia
Alfons G. Hoekstra & Thomas Wriedt,University of Amsterdam, The Neverlands
Peter Nagy % Gyorgy Vereb, Janos Szollsi, University of Debrecen, Hungary
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Additional Information

Publisher
John Wiley & Sons
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Published on
Mar 31, 2011
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Pages
740
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ISBN
9783527634293
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Language
English
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Genres
Science / Life Sciences / Biophysics
Science / Physics / General
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Content Protection
This content is DRM protected.
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Johnjoe McFadden
Michael D. Leinbach
Timed to release for the 15th Anniversary of the Columbia space shuttle disaster, this is the epic true story of one of the most dramatic, unforgettable adventures of our time.

On February 1, 2003, Columbia disintegrated on reentry before the nation’s eyes, and all seven astronauts aboard were lost. Author Mike Leinbach, Launch Director of the space shuttle program at NASA’s John F. Kennedy Space Center was a key leader in the search and recovery effort as NASA, FEMA, the FBI, the US Forest Service, and dozens more federal, state, and local agencies combed an area of rural east Texas the size of Rhode Island for every piece of the shuttle and her crew they could find. Assisted by hundreds of volunteers, it would become the largest ground search operation in US history. This comprehensive account is told in four parts:

Parallel Confusion
Courage, Compassion, and Commitment
Picking Up the Pieces
A Bittersweet Victory

For the first time, here is the definitive inside story of the Columbia disaster and recovery and the inspiring message it ultimately holds. In the aftermath of tragedy, people and communities came together to help bring home the remains of the crew and nearly 40 percent of shuttle, an effort that was instrumental in piecing together what happened so the shuttle program could return to flight and complete the International Space Station. Bringing Columbia Home shares the deeply personal stories that emerged as NASA employees looked for lost colleagues and searchers overcame immense physical, logistical, and emotional challenges and worked together to accomplish the impossible.

Featuring a foreword and epilogue by astronauts Robert Crippen and Eileen Collins, and dedicated to the astronauts and recovery search persons who lost their lives, this is an incredible, compelling narrative about the best of humanity in the darkest of times and about how a failure at the pinnacle of human achievement became a story of cooperation and hope.
Geoffrey West
"This is science writing as wonder and as inspiration." —The Wall Street Journal

Wall Street Journal

From one of the most influential scientists of our time, a dazzling exploration of the hidden laws that govern the life cycle of everything from plants and animals to the cities we live in.

Visionary physicist Geoffrey West is a pioneer in the field of complexity science, the science of emergent systems and networks. The term “complexity” can be misleading, however, because what makes West’s discoveries so beautiful is that he has found an underlying simplicity that unites the seemingly complex and diverse phenomena of living systems, including our bodies, our cities and our businesses.

Fascinated by aging and mortality, West applied the rigor of a physicist to the biological question of why we live as long as we do and no longer. The result was astonishing, and changed science: West found that despite the riotous diversity in mammals, they are all, to a large degree, scaled versions of each other. If you know the size of a mammal, you can use scaling laws to learn everything from how much food it eats per day, what its heart-rate is, how long it will take to mature, its lifespan, and so on. Furthermore, the efficiency of the mammal’s circulatory systems scales up precisely based on weight: if you compare a mouse, a human and an elephant on a logarithmic graph, you find with every doubling of average weight, a species gets 25% more efficient—and lives 25% longer. Fundamentally, he has proven, the issue has to do with the fractal geometry of the networks that supply energy and remove waste from the organism’s body.

West’s work has been game-changing for biologists, but then he made the even bolder move of exploring his work’s applicability. Cities, too, are constellations of networks and laws of scalability relate with eerie precision to them. Recently, West has applied his revolutionary work to the business world. This investigation has led to powerful insights into why some companies thrive while others fail. The implications of these discoveries are far-reaching, and are just beginning to be explored. Scale is a thrilling scientific adventure story about the elemental natural laws that bind us together in simple but profound ways. Through the brilliant mind of Geoffrey West, we can envision how cities, companies and biological life alike are dancing to the same simple, powerful tune.
Ruikang K. Wang
Despite a number of books on biophotonics imaging for medical diagnostics and therapy, the field still lacks a comprehensive imaging book that describes state-of-the-art biophotonics imaging approaches intensively developed in recent years. Addressing this shortfall, Advanced Biophotonics: Tissue Optical Sectioning presents contemporary methods and applications of biophotonics imaging. Gathering research otherwise scattered in numerous physical, chemical, biophysical, and biomedical journals, the book helps researchers, bioengineers, and medical doctors understand major recent bioimaging technologies and the underlying biophotonics science.

Well-known international experts explore a variety of "hot" biomedical optics and biophotonics problems, including the use of photoacoustic imaging to investigate the molecular and cellular processes in living systems. The book also covers Monte Carlo modeling, tissue optics and tissue optical clearing, nonlinear optical microscopy, various aspects of optical coherence tomography, multimodal tomography, adaptive optics, and signal imaging.

With 58 color images, this book represents a valuable contribution to the biomedical and biophotonics literature. Designed for researchers and practitioners in biophotonics, the book is also a useful resource for scientists in laser physics and technology, fiber optics, spectroscopy, materials science, biology, and medicine as well as students studying biomedical physics and engineering, biomedical optics, and biophotonics.

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