Standardization of Quality of Life Core Outcomes in Stem Cell Clinical Trials

Dissertation.com
Free sample

Background: Establishing standardized Quality of Life (QOL) core outcomes in stem cell clinical trials is important to ensure (1) researchers and clinicians can make informed decisions, and (2) clinical trials use and consistently measure the same units (Clarke, 2007; Thornley & Adams, 1998). This study reviews the most common QOL methodologies, timing/frequency of the measurement, and outcomes in cardiovascular stem cell clinical trials.

Methods: To identify instruments, the study reviewed MEDLINE, Scopus, and US Clinical Trials Register through September 2010, and randomized BMSC controlled trials of clinical trials from 2000-2011. The trials all used the terms (bone marrow stem cell AND quality of life OR heart OR cardiac) AND cardiac AND quality of life OR QOL. The study included a Likert scale web-based questionnaire comprised of eight questions designed to assess QOL patient satisfaction post cardiovascular stem cell treatment.

Results: Of the instruments identified, the study found that bone marrow stem cell (BMSC) clinical trials used 35 different types of methodologies, whereas cardiovascular BMSC employed more consistent methodologies. Timing, frequency, and baseline were consistently measured in BMSC clinical trials, whereas cardiovascular BMSC lacked baseline consistency and were measured primarily after treatment. Cardiovascular BMSC outcomes were consistent, whereas BMSC clinical trials had multiple outcomes.

The mean participant age was 56.25 years with a minimum age of 46 years and a maximum age of 61 years. Participants generally were educated with a minimum education level of an Associate degree and a maximum degree of Doctorate. The patient satisfaction survey revealed that participants preferred yes/no questions and surveys that required less than 15 minutes to complete, received via email, easy to understand, not too personal, relevant to feelings, containing a baseline measure, and medical-condition specific.

Conclusion: QOL outcomes are rarely assessed in BMSC cardiovascular trials. Treatments are performed all over the world, and no one knows whether these treatments actually are effective. Both standardized measurements and additional studies are needed.
Read more
Collapse

About the author

Dori Naerbo, PhD, MSBA and MSc is a University of Liverpool graduate and specialises in stem cell clinical trials, commercialisation of cellular treatments and business development. Dr. Naerbo is a successful entrepreneur and author with over twenty years of diverse business experience. Areas of expertise include biotech, clinical research, global knowledge management (KM), R&D (special interest in cardiovascular stem cell applications), life science (Phase I and II), mentoring and crisis management. Dori provides access to her network of world class scientists and researchers in manufacturing, cellular technologies and treatments. Dori speaks English and Norwegian, and holds a Ph.D. in Organisation Psychology, MSc in Business Administration and MSc in Clinical Research. 

Read more
Collapse
Loading...

Additional Information

Publisher
Dissertation.com
Read more
Collapse
Published on
Jul 16, 2018
Read more
Collapse
Pages
92
Read more
Collapse
ISBN
9781612334660
Read more
Collapse
Read more
Collapse
Best For
Read more
Collapse
Language
English
Read more
Collapse
Genres
Medical / Microbiology
Medical / Physician & Patient
Read more
Collapse
Content Protection
This content is DRM protected.
Read more
Collapse

Reading information

Smartphones and Tablets

Install the Google Play Books app for Android and iPad/iPhone. It syncs automatically with your account and allows you to read online or offline wherever you are.

Laptops and Computers

You can read books purchased on Google Play using your computer's web browser.

eReaders and other devices

To read on e-ink devices like the Sony eReader or Barnes & Noble Nook, you'll need to download a file and transfer it to your device. Please follow the detailed Help center instructions to transfer the files to supported eReaders.
Has your doctor lied to you?


Eat low-fat and high-carb, including plenty of "healthy" whole grains—does that sound familiar? Perhaps this is what you were told at your last doctor's appointment or visit with a nutritionist, or perhaps it is something you read online when searching for a healthy diet. And perhaps you've been misled. Dr. Ken Berry is here to dispel the myths and misinformation that have been perpetuated by the medical and food industries for decades.


This updated and expanded edition of Dr. Berry's bestseller Lies My Doctor Told Me exposes the truth behind all kinds of "lies" told by well-meaning but misinformed medical practitioners. Nutritional therapy is often overlooked in medical school, and the information provided to physicians is often outdated. However, the negative consequences on your health remain the same. Advice to avoid healthy fats and stay out of the sun has been proven to be detrimental to longevity and wreak havoc on your system. In this book, Dr. Berry will enlighten you about nutrition and life choices, their role in our health, and how to begin an educated conversation with your doctor about finding the right path for you.


This book will teach you:

- how doctors are taught to think about nutrition and other preventative health measures, and how they should be thinking

- how the Food Pyramid and MyPlate came into existence and why they should change

- the facts about fat intake and heart health

- the truth about the effects of whole wheat on the human body

- the role of dairy in your diet

- the truth about salt—friend or foe?

- the dangers and benefits of hormone therapy

- new information about inflammation and how it should be viewed by doctors


Come out of the darkness and let Ken Berry be your guide to optimal health and harmony!

One of the pastoral problems of religiosity in Slovakia today is that contemporary Christianity is pervaded by nihil-inclinations. Such inclinations manifest themselves in the loss of orientation and meaning, and a disinterest in Christianity, which has by and large remained on a doctrinal, moralistic, and ritual level without offering a constructive faith response to the 'signs of the times'.

This dissertation argues that nihilism is not an entirely negative or morose concept that leaves behind a void or abyss without values, rendering this world meaningless. Nihilism as such is not an absolute (demonizing) danger; rather, it is the failure to adequately engage it that constitutes the pro-nihilizing threat. My analysis of nihilism begins with Nietzsche. In analyzing his texts, I propose my own interpretation of his nihilism. Because of the tensive state of Nietzsche's nihilism, which on the one hand lacks a firm ground of higher values, and on the other, exhibits a recurring tendency to return to these values, I refer to this state as 'nihilism-in-tension'. I suggest that 'nihilism-in-tension' may be conceived as the condition of thought that bears some resemblance to divine kenosis. I argue that kenosis is an appropriate epistemological instrument to disclose the mechanism or unknown function working within 'nihilism-in-tension', and may be described through a transformative kenotic formula ('pro-kenotic-nihil').

To reveal this mechanism, I employ the experiential theory of the sublime as the vantage point from which to uncover the inner constituents of kenosis and 'nihilism-in-tension'. Here I argue that the event which imparts transformative meaning to 'nihilism-in-tension' is the radical imitation of the deepest Christian mystery exemplified in the kenotic life of Christ. This may be expressed in the following formula: nihil and its kenotic radicalization (maximization of nihilism) = annihilation of nihil (negation of nihilism). 

 To apply this mechanism to ecclesial life, I introduce the nada of John of the Cross and the “weak thought” of Gianni Vattimo as two modalities, spiritual and philosophical, that can translate the postmodern condition of 'nihilism-in-tension' into a practical pursuit of wisdom and right relationship. The former transmutes the nihil of 'nihilism-in-tension' from nada to todo, or from self-emptying to union with the divine. The latter transforms the nihil of 'nihilism-in-tension' through the philosophy of “weak thought,” which calls for tentative and non-foundational modes of thought and a weakening of immutable structures. I demonstrate that nada and “weak thought” are appropriate instruments for “weakening” authoritarian church structures and reinterpreting (or rewriting) the tradition in kenotic, inclusive, and dialogical forms. 

This study demonstrates that the kenotic movement of the nihil of 'nihilism-in-tension' into the nihil of kenosis, or fructifying todo, is a potential pastoral instrument to address the problem of nihil-inclinations in the religious context of Slovakia. It attempts to give some orientation to the local Church by raising awareness of its kenotic origins, and offering its theological, spiritual, and philosophical apparatus to approach the problem. 

A scorchingly frank look at how doctors are made, bringing readers into the critical care unit to see one burgeoning physician's journey from ineptitude to competence.

In medical school, Matt McCarthy dreamed of being a different kind of doctor—the sort of mythical, unflappable physician who could reach unreachable patients. But when a new admission to the critical care unit almost died his first night on call, he found himself scrambling. Visions of mastery quickly gave way to hopes of simply surviving hospital life, where confidence was hard to come by and no amount of med school training could dispel the terror of facing actual patients.

This funny, candid memoir of McCarthy’s intern year at a New York hospital provides a scorchingly frank look at how doctors are made, taking readers into patients’ rooms and doctors’ conferences to witness a physician's journey from ineptitude to competence. McCarthy's one stroke of luck paired him with a brilliant second-year adviser he called “Baio” (owing to his resemblance to the Charles in Charge star), who proved to be a remarkable teacher with a wicked sense of humor. McCarthy would learn even more from the people he cared for, including a man named Benny, who was living in the hospital for months at a time awaiting a heart transplant. But no teacher could help McCarthy when an accident put his own health at risk, and showed him all too painfully the thin line between doctor and patient.

The Real Doctor Will See You Shortly offers a window on to hospital life that dispenses with sanctimony and self-seriousness while emphasizing the black-comic paradox of becoming a doctor: How do you learn to save lives in a job where there is no practice?
A riveting exploration of the most difficult and important part of what doctors do, by Yale School of Medicine physician Dr. Lisa Sanders, author of the monthly New York Times Magazine column "Diagnosis," the inspiration for the hit Fox TV series House, M.D.

"The experience of being ill can be like waking up in a foreign country. Life, as you formerly knew it, is on hold while you travel through this other world as unknown as it is unexpected. When I see patients in the hospital or in my office who are suddenly, surprisingly ill, what they really want to know is, ‘What is wrong with me?’ They want a road map that will help them manage their new surroundings. The ability to give this unnerving and unfamiliar place a name, to know it—on some level—restores a measure of control, independent of whether or not that diagnosis comes attached to a cure. Because, even today, a diagnosis is frequently all a good doctor has to offer."

A healthy young man suddenly loses his memory—making him unable to remember the events of each passing hour. Two patients diagnosed with Lyme disease improve after antibiotic treatment—only to have their symptoms mysteriously return. A young woman lies dying in the ICU—bleeding, jaundiced, incoherent—and none of her doctors know what is killing her. In Every Patient Tells a Story, Dr. Lisa Sanders takes us bedside to witness the process of solving these and other diagnostic dilemmas, providing a firsthand account of the expertise and intuition that lead a doctor to make the right diagnosis.

Never in human history have doctors had the knowledge, the tools, and the skills that they have today to diagnose illness and disease. And yet mistakes are made, diagnoses missed, symptoms or tests misunderstood. In this high-tech world of modern medicine, Sanders shows us that knowledge, while essential, is not sufficient to unravel the complexities of illness. She presents an unflinching look inside the detective story that marks nearly every illness—the diagnosis—revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying. Through dramatic stories of patients with baffling symptoms, Sanders portrays the absolute necessity and surprising difficulties of getting the patient’s story, the challenges of the physical exam, the pitfalls of doctor-to-doctor communication, the vagaries of tests, and the near calamity of diagnostic errors. In Every Patient Tells a Story, Dr. Sanders chronicles the real-life drama of doctors solving these difficult medical mysteries that not only illustrate the art and science of diagnosis, but often save the patients’ lives.
©2019 GoogleSite Terms of ServicePrivacyDevelopersArtistsAbout Google|Location: United StatesLanguage: English (United States)
By purchasing this item, you are transacting with Google Payments and agreeing to the Google Payments Terms of Service and Privacy Notice.