Synthesis and biological evaluation of 1,5-diphenylpyrrole derivatives as COX-2 selective inhibitors and NO-releasing agents and development of a novel BRD9 chemical probe

Sara Consalvi

Jun 2020 · Sapienza Università Editrice

About this ebook

This PhD thesis consists of three projects: the first and the second ones, carried out at Sapienza University of Rome, deal with the design and synthesis of novel COX-2 selective inhibitors and dual COX-2 inhibitors/NO-releasing agents, respectively. The third project concerns the development of a novel BRD9 chemical probe and was realized at the University of Oxford (Department of Chemistry).

About the author

Sara Consalvi earned her PhD in Pharmaceutical Sciences in 2015 and is currently a research fellow at Department of Chemistry and Technology of Drugs. Her research focus is on drug discovery, in the field of anti-inflammatory and antimycobacterial agents.