Somehow immune to an unstoppable, incurable virus, military virologist Robert Neville (Smith) is now the last human survivor in New York City and maybe the world. But he is not alone. Mutant victims of the plague lurk in the shadows... watching Neville's every move... waiting for him to make a fatal mistake. Perhaps mankind's last, best hope, Neville is driven by only one remaining mission: to find an antidote using his own immune blood. But he knows he is outnumbered... and quickly running out of time.