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Between stand-up gigs, Kumail Nanjiani is an Uber driver in Chicago. He frequently performs with his fellow comics. Kumail, in the middle of becoming a budding stand-up comedian, meets Emily Gardner. Kumail and Emily go grocery-shopping. At one point, Emily complains about an ache in her foot after she is twisting it slightly during a dance class. Meanwhile, a sudden illness sets in forcing Emily to be put into a medically-induced coma. Kumail must navigate being a comedian, dealing with tragic illness, and placating his family's desire to let them fix him up with a spouse, while contemplating and figuring out who he really is and what he truly believes.