On the season eleven premiere, with Cristina gone, a new doctor, Maggie Pierce, making the rounds, and Derek wanting to move to Washington DC, Meredith struggles to regain a sense of normalcy both at home and in the hospital. Meanwhile, Callie and Arizona come to a decision about surrogacy, Amelia overhears a big secret, Bailey realizes she will have to fight Alex for Cristina's board seat and a freak accident causes two teenagers to be caught in a very compromising position.
In this Maggie centric episode, she continues to try to make a positive impression at the hospital but finds herself in extremely unfortunate situations. Meanwhile, Richard continues to hold onto his secret and the doctors work with a dying woman who is being kept alive by her daughter.
Owen introduces Callie to the Veterans Hospital patients in hopes that she will help them with her robotic limb lab, Jo becomes jealous of Alex and Meredith's friendship, and Maggie continues to confide in Richard. Meanwhile, Alex and Bailey prepare to go in front of the board.
Secrets from Ellis Grey's past come to light when Meredith watches old videos and reads through her mother's journals. Meanwhile, Maggie rocks the hospital with an unexpected announcement; Alex gets new responsibilities and Callie focuses her attention on the Veterans' project.
In this Callie and Arizona centric episode, the couple takes a look into the problems that have contributed to their troubled marriage. At work, Callie immerses herself in the Veterans' project, and Arizona struggles to impress Dr. Herman. Meanwhile, Richard leans on Bailey for advice.
Owen becomes invested in a patient when he realizes she may have served in the military, April's mother pays her daughter a visit and bonds with Jackson, and Derek plans a family dinner. Meanwhile, a patient's diagnosis causes Bailey to reconsider her own health issues and Dr. Herman drops a bombshell on Arizona.
Secrets about Amelia's past addictions come to light and cause problems for her at the hospital; Bailey oversees Jo's first solo surgery; and Arizona must make an executive decision in Dr. Herman's absence. Meanwhile the doctors spring into action when a couple arrives at the emergency room after escaping a fire.
Maggie and Meredith disagree with Derek about the best way to approach a patient's case, which leads to a bigger argument between the couple. Meanwhile, Callie feels responsible when one of her veterans is pushed too far and one doctor's routine procedure results in a devastating diagnosis, on the winter finale.
As Derek prepares for his move to DC, Meredith keeps herself busy at the hospital. Meanwhile, Jackson and April deal with difficult news, and Arizona and Amelia discuss how to best approach Dr. Herman.
April stays optimistic as Arizona begins testing on her baby; Dr. Herman plans out a crash course in fetal surgery; and Owen and Callie encourage each other to get back into the dating scene. Meanwhile, Meredith, Maggie and Bailey use the 3D printer to gain a better understanding of their patient’s tumor.
After several discussions with Dr. Herman, April and Jackson must face their situation head on and make a difficult decision regarding their unborn child. Catherine arrives in Seattle and bumps into Richard at the hospital. Meanwhile, Meredith tries to find someone to take care of the kids so she can visit Derek for the weekend, and Amelia shows Stephanie some tough love when they work together on a case.
Maggie gets upset when Meredith dodges her questions about DC; Bailey and Ben become concerned about Ben's brother after he is admitted to the hospital, and Dr. Herman starts to warm up to Arizona. Meanwhile, Richard feels manipulated by Catherine.
The hospital doctors become fascinated with Dr. Herman's case when Amelia gives a lecture detailing the intricacies of the surgery. Arizona and Herman continue to bond over the amount of cases they are trying to complete before the big surgery. Meanwhile, Bailey brings them a case of a pregnant woman who is close to her heart.
In this Amelia-centric episode, Amelia engages in the surgery of a lifetime as a crowd of doctors look on from the gallery. With Stephanie by her side, she begins operating on Dr. Herman, but quickly realizes it's far more difficult than she anticipated. Meanwhile, Bailey becomes skeptical when Arizona takes on one of Herman’s cases.
An earthquake shakes the ground at Grey Sloan Memorial Hospital, trapping Maggie in an elevator and threatening Meredith's long streak of successful surgeries. Meanwhile, Owen gives medical advice to a child over the phone and Ben confides in Jackson.
A patient's condition sparks a conversation between Richard and Maggie about Alzheimer's disease; April and Jackson struggle to return to their normal lives and Arizona is faced with the reality that Callie is moving on. Meanwhile, Meredith reveals her biggest fears about Derek.
A school field trip to the hospital takes a dramatic turn when the kids witness two injured cops enter the emergency room. Meanwhile, Stephanie sets her eyes on one of the chaperones, Callie operates on the leg of the police captain and Amelia must face her feelings for Owen.
Upon realizing that Owen and Amelia have been seeing each other behind her back, Meredith comes down hard on her sister-in-law causing Amelia to rethink things. Meanwhile, Catherine springs into action when a man is brought into the hospital after his wife seeks revenge on his cheatings ways.
A small plane crash in Seattle causes multiple casualties and brings back horrible memories for the doctors, especially Meredith and Arizona. Meanwhile, friction between Owen and Amelia makes for an uncomfortable working situation for Stephanie.
Ben worries that an innocent conversation with Derek could end up causing problems for Bailey; Cristina turns to Shane as tension with Meredith increases; April's upcoming wedding creates an uncomfortable situation for Stephanie and Jackson.
Couples panic when the hospital announces a nonfraternization policy; Owen and Emma discuss the future; Meredith and Cristina have some girl time; Richard asks the residents for help with a rare cancer case.
Arizona's bad day escalates when she advises a patient on a potential double amputation; Derek breaks a promise; Stephanie and Jo find an abandoned baby; the nonfraternization rule leads to a suspension.
Cristina enlists Meredith to help her prepare an acceptance speech for her possible Harper Avery win and while Owen offers to attend the ceremony with her, she insists on going alone. Meanwhile, Derek feels overwhelmed between his responsibilities at home and at the hospital. April and Jackson come to a disagreement on children and religion, and Callie and Arizona try to reconnect in their marriage.
Jackson is given the daunting task of delivering disappointing news to the doctors. Meanwhile, Derek's sister Amelia drops by for a surprise visit, Richard surprises Catherine in Boston and when Bailey gets frustrated by the slow pace of her research, she makes a risky decision.
Cristina looks to Meredith for advice as she assesses her future at the hospital. Derek and Amelia work together on a difficult surgery involving conjoined twins. Meanwhile, Jo is spread too thin when she tries to work on several cases at once and Stephanie realizes the truth about Bailey's bubble boy case.
With Derek away, Meredith spends time with Amelia and finds out her true feelings about her time in Seattle. Bailey deals with the ramifications of her actions and Callie receives devastating news. Meanwhile, the residents panic after hearing that one of them will be fired.
On the season ten finale, the doctors of Grey Sloan Memorial Hospital bid an emotional farewell to the beloved Cristina Yang. A possible act of terrorism rocks Seattle and causes chaos at the hospital. Meanwhile, Meredith makes a life changing decision and one doctor receives shocking news.
Bailey continues to shut everyone out; Owen worries that Ethan could end up in foster care; a new craniofacial specialist comes to the hospital to work on a young patient; a magician's assistant needs medical attention after a trick goes awry.