When New York homicide detective John Amsterdam says he brings a lifetime of experience to his work, he's not kidding. Amsterdam is immortal -- a former Dutch soldier in the 17th century colony of New Amsterdam who was granted eternal life after saving an Indian girl from a massacre. The spell she wove in gratitude will be broken only when he finds his true love. Dr. Sara Dillane is the physician who treats Amsterdam when he suffers what appears to be a massive heart attack.
While John recovers from his recent gunshot wound, he and Eva investigate the death of a woman who appears to have drowned; John has flashbacks of his life in the 1920s; he questions if Sarah is his soul mate.