An all-girl rock band! Catchy tunes! Exotic adventures! Fabulous hair! Lead guitarist Josie and Pussycats Melody and Valerie sing their way through a slew of escapades as an assortment of busy rascals tries to kidnap, drown and otherwise harass the girls. But Josie and the Pussycats keep right on singing while they circle the globe, bringing music and mayhem wherever they go.
The Pussycats befriend Professor Isaac Belfour, a scientist who invented an invented an invisibility formula. They take him along for their gig in Puddletown, England, to protect him from Mr. X, a former laboratory assistant who stole the formula.