Two subway repairmen are attacked by an oversized lizard and one of them is kidnapped. The Daily Bugle reports show mysterious disappearances throughout Manhattan and rumours of a giant lizard. Publisher J. Jonah Jameson subsequently offers a $1000 bonus to any photographer who can capture an image of the beast. Reporter Peter Parker plans to claim the reward in order to help pay off some of his Aunt May large debts. Peter makes his way to interview his science professor, Dr. Curt Connors, a scientist who works with reptiles. Whilst paying him a visit, he and fellow science student Debra Whitman witness the Lizard exiting their teacher's lavatory.