When charismatic Chief of Surgery Charlie Harris (Michael Shanks) at Hope-Zion Hospital ends up in a coma, he leaves the hospital in chaos, and his fiancée and fellow surgeon, Alex Reid (Erica Durance), in a state of shock. Along with newly-arrived star surgeon, Joel Goran (Daniel Gillies), Alex races to save Charlie's life. As the action unfolds, comatose Dr. Harris wanders the halls of Hope-Zion in "spirit" form, not sure if he is a ghost or a figment of his own imagination. Alex, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the often complicated and courageous decisions that are made in their daily struggle to keep hope alive.
After a major turn of events, Alex is faced with a monumental question: is her life now changed forever? Meanwhile, Joel is in a race against time to save a young patient from rapidly advancing flesh-eating disease.