Manfred Bernardo (François Arnaud), a powerful psychic on the run, decides to hide out in the small, sleepy town of Midnight, Texas. But when he's haunted by the ghost of a recently murdered Midnighter, Manfred discovers this sleepy community is a mysterious safe haven for outsiders with secrets both supernatural and human including Lemuel (Peter Mensah), an energy leeching vampire; Olivia (Arielle Kebbel), a beautiful assassin; Fiji (Parisa Fitz Henley), a witch with a cranky cat; Creek (Sarah Ramos), a spunky writer with big dreams; Bobo (Dylan Bruce), a pawnshop owner with a hidden past; the Rev (Yul Vazquez), who has an obsession for animals; and Joe (Jason Lewis), an angelic tattoo artist. In addition to the colorful residents, Manfred learns the town itself sits on a veil between the living and dead. He pledges to join the Midnighters in the fight to protect their home from suspicious cops and other outside forces.