Thackery sets his sights on a return to The Knick--a request that doesn't sit well with the Board. After a shocking discovery, Cornelia enlists Cleary to do a dirty job, for a price. Bertie makes a change; Henry Robertson pushes a new subway initiative.
Thackery enlists Edwards to help him test a new hypothesis. After rejecting Henry Robertson's advances at The Knick, Lucy learns that confession isn't always good for the soul. We meet Genevieve Everidge, a journalist writing a story about a rival doctor.
Abby's worsening condition persuades Thackery to test out his novel syphilis treatment. Algernon comes clean to Opal, but does not get the response he expects. Cleary makes a last-ditch effort to raise funds for Harriet as her date in court arrives.
A subway explosion leads to an influx of patients at The Knick, but little margin for profit. Pursued by Henry, Lucy takes to heart some advice given by one of Ping Wu's girls. An addict's misfortune gives Thackery a test case for his addiction theory.
Faced with a quandary, Bertie decides to take matters into his own hands at Mt. Sinai, enlisting Algernon to help. Thackery investigates the efficacy of hypnosis, and takes an interest in a pair of conjoined twins.
Fighting his nerves, Thackery readies himself to attempt to separate Zoya and Nika in front of a packed audience. After getting a surprise gift from her father-in-law, Cornelia attends a gala charity ball for the new Knick with other familiar guests.
After dealing with an unwanted intruder, Thackery faces the realities of his addiction research, and sets his sights on improving Abby's appearance. Algernon suspects foul play during his surgical debacle; Gallinger shuffles his family priorities.
Thackery's connection to Captain Robertson, and how the doctor arrived at the Knick, is revealed. The conflict between Algernon and Gallinger comes to a head. Cornelia and Henry weigh the cost of a family crisis.
Season Two Finale. Thackery eschews Zinberg's advice at Mt. Sinai and opts for a dramatic, and risky, alternative course of action. Cornelia and Henry weigh their futures following an alarming family revelation.
Already fuming over the hospital's faulty new electrical system, Thackery tasks Herman Barrow, The Knick's crooked superintendent, to deliver more cadavers so that he and his team can test out novel surgical procedures.
Thackery weighs performing surgery on a former flame, and orders Everett and Bertie to experiment on pigs. Barrow goes to extremes in order to pay off a debt and recover a missing tooth. After a bad day, Algernon takes out his frustrations at a local bar.
Algernon forces Thackery's hand during surgery, angering Gallinger. Abigail, in recovery, regrets her past choices involving Thackery. Cleary and Sister Harriet strike one deal, then another. Lucy learns of Thackery's secret life.
Barrow looks to pay down a debt by treating one of Collier's wounded men at the Knick, and tries to convince Captain Robertson to purchase a new Edison invention. Still marginalized by Thackery, Algernon attempts to improve on a hernia surgery.
The stabbing of a cop by a black man stirs up racial tension on the street and in the Knick. Everett returns to work and a changed OR; Barrow fears for Junia's safety; Cornelia is impressed with Edwards' ingenuity; Lucy is escorted home.
A late-night crime sheds unfavorable light on The Knick, forcing Robertson to come up with hush money. Lucy goes to extremes to get drugs for an increasingly desperate Thackery. Gallinger despairs as Eleanor's behavior becomes more erratic.
Season finale. Refusing to collaborate with Zinberg on blood-transfusion research, an increasingly paranoid Thackery pushes himself to the limit, and beyond, in an effort to solve the riddle and beat his rival. Cornelia and Edwards arrive at a crossroads.