House

Sink your teeth into meaty drama and intrigue, a new take on mystery, where the villain is a medical malady and the hero is an irreverent, controversial doctor who trusts no one, least of all his patients. On the compelling series premiere episode, Dr. Gregory House, a brilliant diagnostician but devoid of bedside manner, and his elite team of young medical experts rush to save the life of a kindergarten teacher (guest star Robin Tunney) who started speaking gibberish and passed out in front of her class. What looks like a possible brain tumor does not respond to treatment and provides many more questions than answers for House and his team as they engage in a risky trial-and-error approach to her case.

When a teen-aged lacrosse player is stricken with an unidentifiable brain disease, House and the team hustle to give his parents answers. Chase breaks the bad news, the kid has MS, but the boy's whacked-out hallucinations disprove the diagnosis and send the team back to square one. As the boy's health deteriorates, House's side-bet on the paternity of the patient infuriates the kid's parents, but may just pay off in spades.

When a college student collapses after a bout of raucous sex with his girlfriend, Dr. House and his team scramble to figure out why. He's got too many symptoms to add up to just one disease and soon his immune system is so perilously compromised a simple cold could kill him. As his condition deteriorates quickly, House needs to think - and get more Vicodin. But when Wilson nags House about his nasty pill habit it proves extremely useful to House, just not in the way Wilson intended.

House exasperates Cuddy when he suggests that two sick babies in one hospital add up to an epidemic. Even more frightening is when it turns out he may be right. As more babies are quarantined and the maternity ward is shut down, Cuddy powerscrubs the hospital and House spars with Cameron and the team over his plan to sacrifice one baby for the good of the rest.

When a nun comes into the clinic with swollen arms, a rash and bleeding in her palms, Dr. House's diagnosis is a bad allergy, not stigmata. However, when he gives her a shot of medication, she has a heart attack, and whether he gave her the correct amount of medicine comes into question. As the nun's case unfolds, the team has to deal with questions regarding their own calling, faith and whether or not they can trust the direction in which their mentor is leading them.

When all signs point to a schizophrenic with deadly DVT lying about her alcohol intake, Dr. House is the lone voice of reason. Under the scrutiny of her hyper-vigilant young son, House takes her off all medication and secretly sends Foreman and Chase to search her apartment for clues. Wading through her altered reality to get to the truth and save her life, House discovers that it isn't mom who's keeping the secrets and reality isn't always what it seems.

When a young wife falls ill to a disease she can't possibly have, House and the team struggle to save her and appease her attentive husband. As her health deteriorates, Foreman bristles that House rides him more than the others, Cameron takes the case way too personally, and a patient with impossibly perfect breasts gives Wilson some medical and personal insights. To save their patient's life, the team has to acknowledge that House is right: everybody lies.

When a high school student falls victim to a mysterious but lethal poisoning, House and his team jump in to find out what is killing the teen. Given a low heart rate and a clean tox screen, House sends Cameron and Chase to the teen's home to find the hot new drug House is sure he's taking. They don't find any drugs, but think they've come up with the answers, until a second unrelated student is admitted with identical symptoms. With the boys' lives hanging in the balance, House and the team have to connect the dots - fast. Meanwhile, an 82-year-old patient has become enamored with House while he helps her figure out the basis of her renewed fascination with her sexual feelings.

Legendary jazz musician, John Henry Giles, checks in to Princeton Plainsboro Teaching Hospital believing he's dying from ALS and signs a DNR to avoid a slow death. Yet House disagrees with the diagnosis and goes against everyone's wishes when he violates the DNR to save Giles' life. The decision lands House in court, drives Foreman to consider another job, and results in Giles' paralysis to worsen. Despite everything, Giles makes a connection with House, and agrees to his treatment. But Dr. Cuddy and the team are not so convinced.

Dr. Foreman believes an uncooperative homeless woman is faking seizures to get a 'meal ticket' at the teaching hospital. But Dr. Wilson grows determined to keep her from falling between the cracks. Her worsening symptoms prove to be a complex mystery, but the mystery of her identity and medical history may hold the answers to saving her life. Just as the team suspects she has contagious meningitis, the woman goes missing, only to be tasered by the police who bring her back. But House deduces that the taser may have proven yet another diagnosis, with dire results.

While trying to figure out why a young patient won't stop bleeding, House takes Cuddy's challenge and goes off Vicodin for a week in exchange for no clinic duty for a month. If House and his team can't determine the source of his patient's blood loss, the 16-year-old car accident victim will die in a matter of days. As House's withdrawal symptoms become more and more severe, his directives for his patient are more harsh and risky than usual, forcing Foreman and Cameron to fear he may not be thinking clearly enough to save the patient's life

A severely broken arm reveals a bizarre case of bone loss and ends the comeback plans of major league pitcher Hank Wiggen. House suspects Hank - with a history of drug use - is lying about using steroids, as his stability worsens. When Hank's kidneys start to fail, his wife offers to donate hers, but she would have to abort her early pregnancy. Forced into an impossible solution, and admitting failure as an addict, Hank tries to take his own life. House must isolate and fix the problem soon if this pitcher's life, as well as his career, can be saved.

A 12-year-old boy believes he's cursed after a Ouija board tells him he's going to die. His father, a major financial supporter of the hospital, makes escalating demands of House and the team as they try to diagnose the boy's pneumonia-like symptoms and incongruous rash. Tension intensifies when House invites Chase's estranged father, a renowned doctor visiting from Australia, into their circle of diagnosticians - much to Chase's discomfort - and House is intrigued by Chase's lack of relationship with his father. When the boy's diagnosis becomes more evident, the young patient is forced to face the idea that his father may not be everything he believes.

Princeton-Plainsboro Teaching Hospital is turned upside-down when billionaire entrepreneur Edward Vogler (guest star Chi McBride) buys his way into becoming Chairman of the Board. Vogler intends to use the hospital as a new biotech venture, meaning they no longer require the financially draining services of one Dr. Gregory House. Meanwhile, a powerful young woman who seemingly has it all (guest star Sarah Clarke) - perfect life, perfect body, perfect job - becomes inexplicably paralyzed. Upon discovering her deadly secret, House finds himself fighting for her life even though it means risking his job and his medical license.

Just before mobster Joey Arnello spills the beans in federal court and enters witness protection, he collapses. Is he faking? A court order instructs House to find out - and fast. House and his team struggle to diagnose and cure Joey while Joey's brother Bill tries to slow things down and keep Joey from testifying. Meanwhile, Cuddy struggles to convince Vogler (guest star Chi McBride) that House is an essential part of the hospital. With Joey mysteriously slipping in and out of a coma, and House's job on the line, House makes an exception to his own policy and gets to know his patient.

When an obese 10-year-old girl presents with a heart attack, House and his team investigate. At first thinking it's an adverse reaction to diet pills, they ultimately uncover a much more deadly source of her illness. Meanwhile, under pressure from hospital management, House tries to figure out which of his team to fire. But once he makes a decision, Vogler doesn't accept it and demands he pick someone else, leading House to suspect one of his team members is giving inside information to Vogler.

At a high-level campaign fundraiser, up-and-coming Senator Tom Wright (guest star Joe Morton) becomes violently ill. Vogler (guest star Chi McBride) pushes House to take Wright's case and also dangles a new incentive in front of him: deliver a speech on behalf of Vogler's pharmaceutical company, and save his whole team. While the Senator's symptoms and tests point to AIDS, a condition which would squash his White House dreams forever, House and the team dig for different answers. Meanwhile, House gives the speech, but it's not exactly what Vogler had in mind.

While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler (guest star Chi McBride) is on the warpath to get House fired. House diagnoses his pregnant patient's illness, but now she and her husband struggle with an emotional and heartbreaking choice: to save her life, or that of her unborn child. Meanwhile, Vogler sets up a board meeting to get rid of House, but when Wilson objects, Vogler lashes out against him and shocks Cuddy and the rest of the board with his decision. Finally, Cuddy takes a stand against Vogler (will she be next?).

While a meningitis scare overwhelms the resources and staff of Princeton-Plainsboro Teaching Hospital, House zeros in on a single patient: a 12-year-old whose symptoms are similar to, but not quite right for, meningitis. Cuddy gives them an hour to crack the case before pulling their medical manpower to treat the countless patients taking over the waiting rooms, but when they discover something quite unexpected, House, Foreman and Chase must devise ingenious ways and locations to treat the girl's delicate condition amid the chaos. Meanwhile, House asks Cameron to come back to her job now that Vogler is gone, but she's got a surprising requirement.

While Princeton-Plainsboro Hospital is rife with rumor and speculation about House's imminent date with Cameron, House apparently scares a meek clinic patient into having a stroke. The team must navigate their way through the patient's odd proclivities, overbearing "friend" and reluctant parents in order to stop the strokes and try to save the guy's life. All the while, Wilson, Cuddy and the team offer House dating advice and lay odds on the outcome.

House's ex-girlfriend Stacy Warner (guest star Sela Ward) returns - not to be with House, but to get his help for her ailing husband. While House decides whether or not to take the case, Cuddy instructs him to substitute for a sick professor and present a lecture to a class of medical students. As he weaves the stories of three patients (including guest star Carmen Electra) who all present with a similar symptom, House gives a lecture the students will never forget. In the end, they come out with a broader understanding of diagnostics and House's team comes out with a greater understanding of him.

House insists he can handle things when Stacy (guest star Sela Ward), the woman he once loved, asks him to diagnose Mark, the man she married. When Mark's tests come back normal yet symptoms show that his brain is dying, the puzzle may be one that even House can't solve. While Wilson worries about House's emotional well-being, the team is blown away by his over-the-top demands. As House struggles to put his emotions aside and solve the case, Cuddy adds to his dilemma and offers Stacy a reason to stay.

When Death Row inmate Clarence (guest star LL Cool J) mysteriously and suddenly collapses after hallucinating, House jumps at the chance to take the case for its difficulty and because it's "cool." Dr. Cameron refuses to treat the patient in protest and feels they should treat a cancer patient because she's more deserving, raising the question: is one life more important than another?

Andie, a 9-year-old terminal cancer patient, is brought in after suffering from a hallucinogenic episode. Wilson convinces House to take the case, but he and his team struggle to diagnose what caused the hallucination. Andie handles the reality of her terminal medical situation remarkably well - so well that House questions the sincerity of her bravery and considers the possibility it may be a medical symptom.

When Cuddy's handyman Alfredo, a young Latino and the sole provider for his family, falls from her roof and develops strange darkened pinkies, Cuddy joins the team in trying to figure out what's wrong with him. Despite everything the team tries, the whole hand becomes infected. A trip to the young man's neighborhood helps them understand Alfredo's desire for a better life for his family, and provides a clue as to what might be causing his deadly illness.

When Dr. Sebastian Charles (guest star Ron Livingston, "Little Black Book," "Sex and the City"), renowned physician and head of an international organization to fight the spread of tuberculosis among the poor in Africa, is rushed to Princeton Plainsboro Teaching Hospital after collapsing, he immediately determines all the symptoms are from TB. Dr. House has a different opinion and requests additional tests to help determine the cause of his illness.

When recent college graduate Carnell drops at a graduation party from internal shocks, he is rushed to Princeton Plainsboro Hospital. With his father Ken at his bedside, it becomes apparent the two have not been truthful with each other in their lives and their major trust issues affect how the medical team gets the information it needs to help solve Carnell's case.

When a famous professional cyclist is brought in after collapsing during a race, House doesn't want to treat him because he thinks he's lying about doing drugs.

Kalvin, a gay man with full-blown AIDS, confronts House in front of his home, demands that House figure out what's causing his illness - besides HIV or AIDS - and collapses at his feet. When Kalvin claims that House assaulted him, Cuddy tells House to give Stacy the facts. House meets with Stacy at her home - armed with some unethically-garnered personal information about her - and he and Stacy share close quarters when he tries to help her exterminate a mouse from her attic, to the chagrin of her temporarily handicapped husband, Mark.

Kayla, mother of two young girls, doubles over with stomach pain during her children's talent show and is rushed to Princeton Plainsboro Teaching Hospital. Six months later, Dr. Chase and Dr. House are being counseled by Stacy in preparation for a disciplinary hearing aimed at determining if either Chase or House made a mistake that ultimately led to Kayla's death and her family's subsequent lawsuit.

Off-track betting gambler Anica (guest star Cynthia Nixon) collapses in front of House while they're both following horse races at the site. Confused by her symptoms and what he witnessed after she collapsed, he instructs medics to take her to Princeton Plainsboro and takes her case. After the team discovers she's been seeing a number of doctors for a variety of supposed illnesses, everyone but House thinks it's Munchausen's, a disease that causes people to fake symptoms for the medical attention.

Journalist Fletcher Stone (guest star Michael O'Keefe) collapses at his editor's retirement party and hits his head on a table. When he comes to, his sentences don't make sense, and he is rushed to Princeton Plainsboro Teaching Hospital. Since House and Stacy are out of town defending House's Medicaid billings, the team struggles to solve the case on its own. Meanwhile, House and Stacy realize they still have feelings for each other, and when a storm comes through Baltimore, their return flight is cancelled and they are forced to share a hotel room together - further turning up the heat between them.

Margo (guest star Julie Warner), a young housewife on fertility medication, is brought to Princeton Plainsboro Hospital when her inexplicable muscle flailing causes her to crash her car. As Margo's symptoms progress, House and the team think she might have Huntington's disease but when Margo descends into paranoia, they must dig deeper to figure out the cause of her illness - and the team is once again reminded that everybody lies.

When a young man comes into the hospital severely burned, but with some unusual activity going on in his blood tests, House and his team have a difficult challenge. How can you diagnose a burn victim when you are unable to use your normal testing methods?

Dr. House treats a teenage supermodel for heroin addiction and, in the process, uncovers a startling secret about the girl. Meanwhile, Wilson hopes that House's increased leg pain indicates that his leg nerves are regenerating.

When Henry (guest star Howard Hesseman) experiences a seizure but is not aware of it while it's happening, House takes on the case. The team's differential diagnosis points to a bacterial infection, but Henry suffers a heart attack before the treatment for his infection is able to work, prompting the need for a heart transplant. Racing to find a heart donor in time to treat Henry before the infection kills him, House finds an organ donor who's been declared unfit due to a mysterious illness.

House and his team take on a new patient, Bob, who comes to Princeton Plainsboro Teaching Hospital after suffering from a breathing attack while role-playing in the bedroom with his wife (guest star Samantha Mathis). All the symptoms point to heavy metal poisoning, but the tests do not. Meanwhile, as the team goes through its diagnostic process, House is wreaking havoc in the clinic, telling a patient that he got a sexually transmitted disease from his wife.

Melinda (guest star Michelle Trachtenberg), a rebellious teenage girl who is immunocompromised as a result of medications she's taking after a heart transplant, has a severe allergic reaction and goes into shock despite living in a "clean" room. House and the team step in to figure out exactly what caused the reaction, but end up playing referee between Melinda, her overprotective mother (guest star Mel Harris) and her boyfriend.

It's poker night at Princeton Plainsboro when the hospital hosts an oncology benefit. A 6-year-old boy is brought in exhibiting symptoms that aren't too unusual; however, when House learns of additional specifics, he jumps on the case right away. He's seen this set of unique symptoms before - in a previous case when an elderly patient lost her life.

A young woman, Hannah, hasn't been able to sleep for 10 days. She's brought in after she downed an entire bottle of sleeping pills and still didn't fall asleep.

When 15-year-old faith healer, Boyd, is admitted and claims he can talk to God, House takes the case. House thinks the kid is a clever con until the boy touches one of Wilson's cancer patients and causes her cancer to go into remission.

Part 1 of 2. A police officer is admitted in critical condition with a gunshot wound to the head and symptoms that include unexplained giddiness. With no explanation for the odd symptoms, House dispatches Dr. Foreman to the officer's apartment to see if he can gather any clues or possible causes. As the officer's case worsens, Foreman begins to exhibit the same early symptoms and is put in isolation with the patient until House and the team can make a diagnosis.

Part 2 of 2. The police officer is dead, and Foreman continues to experience the same dire progression of symptoms: blindness, muscle contractures and excruciating pain. Foreman realizes he very well may be facing death and tries to make amends in his life. He calls his father (guest star Charles S. Dutton), who travels to be at his son's side. House, Cameron and Chase try everything they can, including infecting him with another disease.

When young mother Kara has a seizure while bathing her child, it causes the near drowning of her newborn son. Unable to determine the cause of Kara's seizures, House and the team race to find what's wrong with her while simultaneously trying to bring her infant back to life. When both mother and son develop complications, Kara's husband must make some very difficult decisions.

A 16-year-old female Hurricane Katrina victim suffering from hallucinations about the tragedy is brought to House by his ex-bandmate Crandall (guest star D.B. Sweeney), who tells House he recently found out she's his daughter. House takes the case despite feeling more pain than usual in his leg. He wants to run a paternity test to make sure his friend is not being scammed, but Crandall refuses.

As House and his team work on the diagnosis of Vince, a man with a giant swollen tongue, disgruntled former patient Jack Moriarty (guest star Elias Koteas) walks into House's office and shoots him. House continues to treat Vince from his hospital bed in the ICU with Moriarty, shot by hospital security and handcuffed to his bed, as his roommate. Mysteriously since the shooting, House feels decreased pain in his leg.

House is back at work after recovering from multiple gunshot wounds and takes on two cases simultaneously - one of which he pushes to the edge of medical treatment, prompting Cuddy and the team to question his motives.

House and the team fight to save a young boy who claims he's being experimented on by aliens, while Cuddy and Wilson withhold the truth from House that he really was right on his last case.

House and the team are pulled in differing ethical directions when their patient asks them to help him end his life.

House tries to decipher an autistic boy's signals in order to diagnose what is causing him to scream.

House and his team race to save a young couple but have to look beyond the bonds of marriage to discover the answer.

A 600-pound man is admitted to the hospital after he is found in his apartment in a coma. House and his team must look past their obese patient's exterior in order to diagnose his illness.

The bonds between father and son are redefined as House awakens a man who's been in a coma for 10 years to gain family history in order to try to save his son's life.

A young man forced to take on the role of father to his young siblings is faced with a choice that could potentially save his life or break up his family; and Tritter has put serious pressure on Wilson to admit he knows the truth about House's use of pain medication

House takes a young patient's parents to court in order to get his course of treatment enforced and Tritter offers Foreman a deal to come clean about House's drug use.

Furious that Wilson has struck a deal with Tritter, House takes on the case of a young dwarf with an unexplained illness that's killing her.

House makes a last ditch effort to avoid jail time and the team takes on the case of a firefighter with a secret so guarded he's willing to risk his life to keep it from being revealed.

While on compulsory clinic duty, House encounters a rape victim who challenges him to unravel a very different kind of medical puzzle.

House is on a mission to get his handicapped parking spot back while he and the team take on the case of a teenage gypsy whose family refuses all modern medical treatments.

House diagnoses an injured young woman unable to feel pain, as he and the team search to find the source of her condition.

House encounters a brain-damaged musical prodigy with inexplicable abilities while the team faces serious concerns about House's own health.

The team examines an ex-Marine suffering from mysterious symptoms since returning home from duty while House deals with an ailment of his own.

When a pregnant celebrity photographer's unborn child endangers her health, the team must take action before it is too late to save either of them.

House and Cuddy board a flight back to the United States from Singapore, where a violent illness is spreading among passengers on the flight, putting their own lives in danger.

House's latest patient is 6-year-old Lucy, who collapsed at daycare with ailments well beyond her years.

The team takes on the case of Lupe, a young female scam artist who passes out while working a card-playing scheme on the streets. Foreman's diagnosis of this young underprivileged woman forces him to examine his own life while House attempts to investigate Wilson's love life.

House and his team go to extreme measures to diagnose a young boy so he can in turn save his dying older brother's life. With Nick's immune system completely wiped out from chemotherapy, Wilson is extremely cautious about keeping him healthy before the transplant.

Foreman hands in his resignation while the team races to diagnose a young college student who coughed up a mouthful of blood during karate class.

Obnoxious 16-year-old chess prodigy Nate is admitted to Princeton-Plainsboro suffering from intense head pain that came on after he attacked his opponent during a speed chess tournament.

A couple travels across the ocean in search of a diagnosis from House.

When an office building collapses, House has to work fast to diagnose a young woman, Megan, who survived the disaster. Due to her injuries, Megan's only form of communication is blinking. House, without a team since Foreman and Cameron quit and he fired Chase, talks through his ideas with a janitor at the hospital. As Megan's condition worsens, Cuddy puts pressure on House to hire a new team, but House defiantly ignores her, and Wilson resorts to desperate measures and hits House where he knows it will hurt. As House persists in diagnosing Megan by himself, he realizes that the case is not what it appears, and that solitude may not be the answer.

House has relented in regard to interviewing potential team members, but he's doing it his own way. He has called in all 40 applicants for the open spots on his team (including guest stars Olivia Wilde, Kal Penn, Peter Jacobson, Anne Dudek and Edi Gathegi), each numbered individually by runners' bibs, and puts them to the test in a Darwinian trial period. As he drills the fellows and arbitrarily fires some along the way, he is approached by a fighter pilot named Greta, a candidate for NASA's astronaut training program. Greta suffers from a neurological disorder in which she is converting visual images to sound, or hearing with her eyes. Knowing that NASA would reject any possibility of her becoming an astronaut if they knew of her problem, Greta begs House to treat her in secret. Keeping her identity private, House takes the case to his fellowship candidates and pits them against one another to come up with an accurate diagnosis. Meanwhile, House is ruffled when he thinks he sees Cameron, Chase and Foreman in the hospital hallways.

The final 10 fellowship candidates compete ferociously when House splits them into two teams by gender. They are assigned to diagnose and treat a wheelchair-bound man with muscular atrophy who is slowly suffocating. As the two teams are trying to one-up each other, complications arise when one team treats the patient but doesn't follow through to make sure their treatment was executed. While the students are busy with their assignment, House experiments on himself to see what happens in the moments when people hover between life and death. Meanwhile, Foreman runs his own team of fellows in his new job at another hospital, and resorts to using a very "House-like" treatment to help a patient

When a 20-year-old funeral home cosmetician, Irene, has a massive seizure, she hallucinates that the cadavers in the funeral home have come to life, House and the remaining seven fellowship candidates must figure out the cause. Thinking something in the funeral home may have made Irene sick, House sends the candidates on some less-than-desirable investigative missions, including a visit to a graveyard. As Irene's symptoms become more life-threatening and her ghostly visions more vivid, House surmises that connecting with Irene's mother might be the best route to diagnosing her illness. Meanwhile, Foreman finds his "House-like" reputation has preceded him as he interviews for a new job, and House must narrow down the candidates from seven to six.

The team takes on the case of a man who collapsed while being mugged. When the man complains of new symptoms that do not fit his initial admission profile, the team suspects he is a hypochondriac. As Mr. X continues to fall ill with symptoms unrelated to his neurological disorder, Foreman and the remaining six fellows are assigned to keep watch, and are bemused as they see their own behavioral idiosyncrasies reflected through him. As they attempt to diagnose this human chameleon, they seem to learn more about themselves than their patient, whose true identity is a mystery. Meanwhile, Cameron and Chase keep a running pool on whom House might cut next from the team of candidates, and Foreman engages in a power struggle with House and Cuddy.

House is recruited by the CIA to help diagnose a deathly ill agent with an unknown illness. The agent's medical case is being spearheaded by Dr. Samira Terzi (guest star Michael Michele), who offers up very little information about the agent's history or previous assignments. With limited information to go on, House uses some unorthodox methods to try to crack the code and determine a diagnosis in time to save his mystery patient's life. Meanwhile, Foreman faces resistance from the remaining six fellowship candidates when they question his judgment and argue over the diagnosis of a female drag car racer who passed out after a race.

A documentary film crew is chronicling a teenager with a major facial deformity who opts to undergo a dramatic reconstructive procedure. When the patient suffers a heart attack just prior to the surgery, House and the team are called in to determine the cause, since the surgery cannot proceed until the patient's cardiac condition is diagnosed. With the film crew covering their every move, Cameron and Chase are especially self-conscious, and House looks for ways to escape from the cameras. Meanwhile, House finds himself distracted by several of the candidates vying for a spot on his team, and he questions his motives for having chosen them.

House encounters a magician whose heart failed while performing an underwater escape act. While the remaining fellowship candidates work to diagnose the illusionist, House is determined to prove that he's a scam artist faking his ailments to cover up the fact that he nearly drowned during his act. During the testing, House suspects one of his own candidates may have an undisclosed illness. In the meantime, House pits his team against one another in a challenge involving Cuddy, granting the winner immunity from elimination and a chance to nominate two other candidates to be put on the chopping block.

When Cuddy puts the pressure on House to choose the final members of his team, House deliberately assigns the candidates to a particularly challenging case - an uncooperative, over-the-hill former punk rock star with a history of drug abuse and civil disobedience. House informs the candidates their potential future depends on correctly diagnosing the patient. As the candidates race to find out if the patient is ailing due to drug abuse, an underlying disease or an unknown condition, House keeps a running tally of their efforts, making a few arbitrary point deductions along the way. Meanwhile, Wilson informs a former patient whom he had previously diagnosed with terminal cancer that he is going to live, and the news throws a wrench in the man's carpe-diem lifestyle.

House and the team treat a woman who suffers from a sudden paralysis of the hands that causes an injury to her daughter while she's spotting her at an indoor rock-climbing wall. As House probes the woman and her injured daughter for any leads as to what might be causing her condition, House is convinced that the woman is withholding information. When the woman's daughter reveals some very descriptive details about her mother's personal life, House isn't so sure the woman hides anything about herself from the people around her, especially her daughter. As the team runs tests to find out what caused her paralysis, the woman loses her eyesight and her system begins to shut down, and House and the team are baffled as to whether it is the woman herself, or her own physiology that is lying to them. Meanwhile, House lets his team participate in a Secret Santa gift exchange, but he puts his own twist on the holiday tradition.

When Dr. Cate Milton (guest star Mira Sorvino), a psychiatrist trapped at the South Pole and the research station's only doctor, becomes ill in the middle of her assignment, she and Dr. House are thrust into a long-distance relationship of sorts. Unable to get Cate out or any additional medical supplies to the South Pole station, House and his team must resort to treating her via webcam. House and his team walk the doctor through a series of makeshift and painful diagnostic tests she must perform on herself. Cate pushes back at House's every recommendation, and is unwilling to risk valuable station medical supplies until he can provide valid proof for his diagnoses each step of the way. While House and his team helplessly watch her condition worsen, House's usually icy demeanor surprisingly softens as he searches for ways to save her life. Meanwhile, House does some detective work of his own and is surprised to learn who Wilson has been dating.

House and the team encounter a woman admitted to Princeton-Plainsboro after she collapsed at her wedding. Her test results come up negative for a variety of common diseases, which leads the team to suspect foul play. When they discover the woman had been a music producer living in the fast lane until she converted to Hasidic Judaism, House insists that people do not change so easily, and that her seemingly rash decision may have something to do with an underlying condition. The woman's husband insists that House treat his wife for her illness, rather than for her past, but she continues to fall dangerously ill. The team must run through all possible diagnoses without disturbing her newly found religious beliefs before it is too late. Meanwhile, House is preoccupied by Wilson's newly-outed relationship with a woman whose personality is remarkably similar to House's.

House suspects an emergency room patient has a bigger problem then the E.R. initially diagnosed based on the fact that the patient is too nice. A skeptical House questions the patient's sunny disposition as the team tries to get to the bottom of his illness, but disagrees with House that niceness is a symptom. Meanwhile, House and Amber are at odds about how much time they each get to spend with Wilson, and Cuddy demands House give his team performance reviews.

House is convinced one of the actors (guest star Jason Lewis) on his favorite soap opera, "Prescription Passion," has a serious medical condition after observing his symptoms on television. House decides to intervene and take matters into his own hands, but both the actor and House's own team dismiss House's assessment and do not believe there is anything wrong with him. Meanwhile, much to House's delight, Amber and Wilson have their first argument, and Cuddy tries to keep up appearances when an inspector makes an unexpected visit to Princeton-Plainsboro.

In the first part of a two-part season finale, House finds himself dazed, confused and covered in blood after surviving a bus accident that left dozens seriously injured. Unable to clearly recall the events leading up to the crash due to his head injuries, House becomes convinced through his flashbacks that a fellow bus passenger was exhibiting signs of a deadly illness prior to the crash. Much to the team's dismay, House pushes through the pain of his own injuries, desperate to piece together the fragments of his shattered memory in order to save someone who might not even know he or she could be dying.

In Part Two of the two-part season finale, House remains inhibited by injuries sustained from a bus accident that has also left a victim rapidly deteriorating from a mysterious condition. Clues inside House's head hold the key to a patient's condition, and House's friendship with Wilson is tested beyond limits as murky memories from the bus accident the night before threaten to change their lives forever.

Eight weeks after the death of his girlfriend, Amber, Wilson is still mourning her death, and his relationship with his best friend House is shattered. Needing to make a change in his life and give himself time to recover emotionally, Wilson resigns from Princeton-Plainsboro. He is forced to decide if House is a destructive force in his life, while House has to determine if he's responsible for the death of his best friend's girlfriend. The team must push forward as they encounter a case involving an assistant to a high-profile executive, who is a textbook "Type A" personality. The team suspects that the patient's symptoms stem from her obsession to constantly please her demanding boss. However, her shocking medical condition forces the team to rethink their initial diagnoses and see the case through House's eyes. Meanwhile, Cuddy attempts to salvage the irreparable rift between House and Wilson, and Thirteen struggles to treat the patient objectively without bringing the reality of her own medical condition to the case.

When several people die suddenly and without warning five years after receiving transplants from a single organ donor, House and the team rush to save the only two surviving recipients. With one already dying and the other healthy but sure to fall ill at any moment, the team must find out what was wrong with the original organ donor. As the team sorts through the records on the deceased donor recipients to find the common thread, they must deal with a new intrusion. House has hired Lucas (guest star Michael Weston), a private investigator, to dig up information about the deceased despite the team's skepticism. Meanwhile, House auditions new best friends to replace Wilson, and soon uses Lucas for his own personal means to spy on Wilson and the other team members.

House and the team take on the case of a struggling artist (guest star Breckin Meyer) who has been painting bizarre portraits. His undiagnosed illness is distorting his perception, threatening to undermine his career, his relationships and everything else in his life. The team soon finds out that he hasn't sold anything lately and is on three separate drug trials to pay the bills. House must unlock the puzzle of which drugs are causing which symptoms before it's too late. Meanwhile, House continues to have private investigator Lucas Douglas (guest star Michael Weston) dig up dirt on everyone on his team, including Taub who is having trouble in his marriage.

When House receives word that his father has passed away, he brushes off the news and dismisses the idea of going to the funeral. However, he is soon coerced into going despite his strongest protests. Back at Princeton-Plainsboro, the team encounters the case of a young woman adopted by American parents who collapsed while in China looking for her birth parents. With House en route to his father's funeral, he must work with the team to diagnose the woman via cell phone while on the road. The team runs through possible diagnoses and various genetic disorders, but when House's phone dies, the team must decipher what House was trying to tell them before the girl's condition deteriorates. Meanwhile, the back story of how House and Wilson met for the first time is revealed.

When a woman with whom Thirteen had a one-night stand falls ill and has a seizure at Thirteen's apartment after a night of partying, Thirteen accompanies the woman to Princeton-Plainsboro where House and the team take on her case. House jumps on the opportunity to delve into Thirteen's personal life, and he and Foreman search Thirteen's apartment to find any possible causes of the woman's illness. Thirteen suspects the woman's drug use has caused her condition, but she soon finds the patient has a long medical history and has seen several doctors over the past few years. She soon finds out the patient slept with her only to get to Dr. House, and that she had been trying to get House to take her as a patient for over a year. Foreman sees evidence of Thirteen's hard-partying lifestyle and confronts her about her self-destruction, warning her that her attitude is sending her life and her job into a downward spiral. Meanwhile, House keeps his private investigator, Lucas (guest star Michael Weston), hot on Wilson's trail.

The team takes on the case of a dreary middle-aged man who has been experiencing unexplained recurring blackouts and time lapses. With possible diagnoses ranging from a stroke to a concussion to toxins from the consumer products he has been testing for work, they soon find that the man, who is raising his 12-year-old daughter on his own, has been experiencing intense sleepwalking spells. As the team tries to find out what he could be doing during his sleep to make himself sick, his condition continues to deteriorate and his daughter also falls gravely ill. Meanwhile, House finds out Cuddy is going to adopt a baby that is due in two weeks. But when Cuddy meets the birth mother in person and notices a strange rash on her arm, Cuddy brings the mother to Princeton-Plainsboro where her condition worsens. Cuddy must take on the case as both a doctor and a potential mother, and she and the team are faced with a heart-wrenching decision that could risk either the birth mother's or the baby's life.

When an agoraphobic man falls mysteriously ill and adamantly refuses to leave his home to get treatment at the hospital, House and the team go to him to figure out what might be wrong. Cameron takes charge as she has treated the patient before, and she and the team figure out ways to bring the hospital to the patient's home, much to Cuddy's disapproval. But as the patient's condition worsens and their options for treating him inside his home become increasingly limited, House and the team scheme to get the man into the hospital for surgery without causing any further physical trauma or emotional anxiety. Meanwhile, Cameron and Chase attempt to work through some kinks in their relationship, and House deals with an annoying itch he cannot seem to scratch as Wilson comes up with his own analogies about House's prickly situation.

The team takes on the case of a 16-year-old factory manager who fell ill when her lungs suddenly filled with fluid while at work. The teenager informs House and team that she is an emancipated minor living on her own and supporting herself, and has ever since her parents passed away. The team begins treatment for suspected heart problems, but when Kutner chooses to sympathize with the patient rather than follow House's directions, he and the team find out the hard way that the girl may not be telling them the truth. Meanwhile, Foreman asks for House's permission to work on a clinical trial and House rejects his proposal. In an effort to prove himself capable of working without House's supervision, Foreman takes on his own pediatric case. But when the unexplained illness brings the child to the brink of death, Foreman is left questioning his ability to work free from House's custody.

A gun-wielding man from the waiting room at the Princeton-Plainsboro clinic takes House, Thirteen and several patients from the waiting room hostage in Cuddy's office. The man claims to be sick with a long undiagnosed illness and demands medical attention from the best doctor in the hospital, threatening to kill any hostages necessary along the way. With a room full of already sick patients, House must use them as guinea pigs to assure the hostage-taker that the medications he is administering to him are legitimate. As Cuddy and the rest of House's team communicate with House over the phone to run tests and offer possible diagnoses, they ponder the possibility that the hostage-taker has nothing physically wrong with him and that everyone in Cuddy's office could wind up dead. With one hostage already shot, Thirteen wagers her own already diminished health as she simultaneously receives the experimental treatments the hostage is receiving. Her life lies in danger as House's own determination to diagnose the hostage-taker threatens to thwart the SWAT team's plan to put an end to the standoff.

House and the team take on the case of a high-profile fitness trainer who collapses while shooting an infomercial. As the team tests her for possible conditions such as exercise-induced asthma, steroid abuse or even a possible vitamin deficiency due to her strict diet, the patient's condition continues to worsen. Though she touts herself as an all-natural fitness guru, the team soon discovers she has a slimming secret that may be contributing to her deteriorating condition. Meanwhile, Thirteen begins her participation in a clinical drug trial for Huntington's disease led by Foreman, Kutner sets up and runs an online medical advice clinic under House's name and Cuddy moves into House's office while hers is being repaired, much to the dismay of her new officemate.

House and the team encounter a teenager who collapsed during her high school Christmas program. They soon find the troubled teen dealt with more than her share of bullying at school, and as her condition continues to deteriorate, the team must delve deeper to get to the bottom of her mysterious illness. Foreman continues to work with Thirteen on the Huntington's disease drug trial, and their relationship progresses when he learns a valuable lesson from her. House gives a clinic patient an unbelievable holiday gift and keeps the team guessing about who may have sent him a particularly thoughtful Christmas present. Meanwhile, Cuddy receives an unexpected gift of her own.

At Cameron's urging, House and the team take on the case of a man living with such severe chronic pain that he tries to kill himself, unable to go on after living for years without a diagnosis or any relief from his suffering. As they try to determine whether the man's pain is psychosomatic or caused by a physical disease, parallels between the patient and House's experiences with excruciating, prolonged pain become apparent. When the patient again attempts suicide under the team's care, their search for answers becomes urgent. Meanwhile, Foreman and Thirteen explore their now complicated relationship as they work together on the Huntington's disease clinical drug trial, and Cuddy finds that taking care of her newly adopted baby leaves her little time to run a hospital and baby-sit House at the same time.

Cuddy decides to spend more time at home to take care of her newly adopted baby and passes some of her day-to-day responsibilities off to Cameron, including supervising House. Cameron is forced to play House's games and becomes involved in a power struggle as he and the team take on the case of a Special Education teacher who collapsed after spitting up blood in the middle of class. As House tests Cameron's tolerance for his extreme measures, the patient continues to fall ill and House insists the teacher's seemingly inherent goodness is actually a pathology. Meanwhile, Foreman must make a critical decision regarding Thirteen's participation in the Huntington's drug trial.

100th Episode Milestone! House and the team take on the case of a woman who collapsed in the middle of a cooking class, and they soon learn she is a highly-renowned cancer researcher who recently gave up her entire career in order to pursue her own personal happiness. Though the team struggles to understand how the woman could give up saving lives for the sake of her own contentment, each grapple with the pursuit of happiness (or lack thereof) in their own lives. As the patient's condition continues to worsen, so does Thirteen's as she begins to suffer serious and life-threatening reactions to the experimental Huntington's Disease clinical trial. Meanwhile, Cuddy attempts to make House's life miserable for him in retaliation for his part in her own unhappiness.

When a priest who runs a homeless shelter sees a bleeding Jesus hovering at his doorstep, he is admitted to the ER. House takes on the case as a distraction for the team while he confronts Foreman and Thirteen about their relationship. The team soon learns the priest had been involved in a molestation scandal that caused him to lose his faith. However, just as they are about to dismiss his case, the patient's condition takes a drastic turn for the worse, and House grapples with his past and his belief.

The team encounters a teenage boy who collapsed from severe pelvic pain after playing basketball. Tests reveal the boy has genetic mosaicism, or both male and female DNA, and the boy's parents inform House and the team that the boy is unaware of his condition. They consciously chose a gender for him when he was born and raised him accordingly, never telling him about his unique condition. However, when his condition worsens and his life is threatened, the parents wonder whether they made the right decision. Meanwhile, Cuddy and Wilson suspect something is wrong with House when he starts acting way too nicely. When they discover the shocking answer, they must face the prospect that House may be changed forever.

House and the team take on the case of Nick (guest star Jay Karnes), a book editor who loses his inhibition and starts insulting coworkers at a dinner party one night before falling ill. The team realizes Nick has frontal lobe inhibition, which has caused him to lose his filter and vocalize all of his innermost thoughts, resulting in extremely insulting outbursts. As Nick's free speech lends to some amusing and insightful comments regarding the team, he must deal with the consequences of being unable to lie to his wife and everyone else important in his life. Meanwhile, House suspects Wilson and Taub are keeping something from him when he catches them both in a lie. House is determined to get to the bottom of it.

House and the team take on the case of Morgan (guest star Judy Greer) who works in a nursing home with a pet cat who only sleeps next to people if they are about to die - and does so with alarmingly accuracy. When it seems the cat has predicted her own death, Morgan, convinced she is about to die, fakes a seizure in order to get to House to have him diagnose her before it's too late. House dismisses her as a nut job, but is intrigued with the claim about the cat and sets out to disprove Morgan's theory. When she falls seriously ill, he and the team are forced to get to the bottom of her mysterious illness - as well as the mystery of the cat with the kiss-of-death. Meanwhile, Taub struggles with his finances and reconnects with an old high school friend at the clinic whose business successes present Taub with an entrepreneurial opportunity he had not previously considered.

We find ourselves inside the mind of Lee (guest star Mos Def) as he awakens after a bicycle accident in New York unable to move or communicate verbally. From his unique perspective, we hear Lee's inner thoughts as House, injured in a motorcycle accident, occupies the hospital bed next to him. House takes notice of Lee as his doctor writes him off as being brain-dead and begins to arrange his organ donations. However, House confirms that Lee is not brain dead at all, but rather has "locked-in" syndrome - he is completely conscious but unable to let anyone know. As House develops a system to communicate with Lee by having him blink once for "no" and twice for "yes," he is intrigued by the case and tries to figure out what is causing Lee's condition, much to the disdain of the presiding physician. When House gets Lee transferred to Princeton Plainsboro, the team is on the case to try to save Lee. As we learn more about Lee and his family, we also see House and the team through Lee's unique perspective, lending insight into their not-so-transparent relationships. When Lee loses his ability to blink and continues to fall ill, the team must race to find the key to unlock his condition. Meanwhile, Wilson suspects House is hiding something from him when he refuses to divulge why he was in New York when he got into his motorcycle accident.

Charlotte, an older woman who has spent the last six months taking care of her husband Eddie (guest star Meat Loaf), is rushed to Princeton Plainsboro for immediate treatment after collapsing from respiratory failure at Eddie's deathbed. With both in the hospital, the husband and wife team become a double mystery when Eddie's condition sporadically improves while Charlotte's condition is deteriorating. The urgency of Charlotte's medical condition breathes new life into their romantic relationship, and their regrets of what could have been are replaced with tenderness as Charlotte informs the team she wants Eddie to have her heart should she die before him. The team is forced to make a difficult choice as both of their lives are nearing an end.

Cameron postpones her vacation with Chase in order to ask House to accept the case of an environmental radical who collapsed at a protest with unexplainable symptoms. Although suspicious of her motives, House agrees. Since she pushed him to take the case so emphatically, House forces Cameron to take the lead and run many of the tests on the patient. Meanwhile, House is unsure of Wilson's new healthy diet.

The team takes on the case of a deaf 14-year-old named Seth who collapsed after he started "hearing" explosions while competing in a wrestling match. When the team tries to test him for seizures, Seth loses vision in one eye, complicating House's bunk theory of "Exploding Head Syndrome." As his condition worsens, the team has an ethical disagreement about the patient and his mother's adamant decision to forego cochlear implants to supplement his hearing. When the prospect of giving Seth the ability to hear for the first time in his life arises, House and the team are faced with a resounding decision. Meanwhile, House's lack of sleep starts to play tricks on his mind, but he finds his insomnia may be a gift instead of a burden.

House and the team take on the case of a ballerina (guest star Jamie Tisdale) whose lungs collapse in the middle of a performance. When the treatment causes her skin to fall off, the dancer faces not only the prospect of never dancing again but also of dying an agonizing death. The team must use their imaginations to carefully choreograph ways to test and treat her delicate body without killing her. Meanwhile, House continues to suffer from a severe lack of sleep and is still haunted by Amber (guest star Anne Dudek). While enlisting Wilson's help to diagnose himself, he is willing to do the unthinkable to make his visions stop.

House and the team are intrigued by Scott, a man whose left brain and right brain operate independently, leaving him with two distinct personalities and no control over some of his actions. As the two sides of Scott's brain struggle for dominance, his warring personalities make it increasingly difficult for the team to figure out what is causing the unique problem. The team is forced to use some unusual methods to get him to cooperate with their necessary testing. Meanwhile, when House refuses to make an appearance in the clinic, Cuddy takes an unconventional approach to force House to make up the time with a particular patient (guest star Carl Reiner).

House begins a detox program at Mayfield Psychiatric Hospital to get the vicodin out of his system in an attempt to control his hallucinations. House plans to leave the treatment facility once he is clean, but he is strong-armed into staying by his attending physician, Dr. Darryl Nolan (guest star Andre Braugher). Dr. Nolan agrees to write a recommendation to reinstate House's medical license only if House agrees to further treatment. When House is moved to a new ward in the hospital, he develops a close relationship with his new roommate, Alvie (guest star Lin-Manuel Miranda), and Lydia (guest star Franka Potente), a frequent visitor who helps House bend the rules. House asks Alvie to help him uncover incriminating information about Dr. Nolan that would allow him to blackmail his way out of the treatment center and convinces Lydia to loan him her car to sneak out a delusional patient in an attempt by House to undermine Dr. Nolan's course of treatment. But when devastating events ensue, House is humbled into reluctantly accepting help.

House begins a detox program at Mayfield Psychiatric Hospital to get the vicodin out of his system in an attempt to control his hallucinations. House plans to leave the treatment facility once he is clean, but he is strong-armed into staying by his attending physician, Dr. Darryl Nolan (guest star Andre Braugher). Dr. Nolan agrees to write a recommendation to reinstate House's medical license only if House agrees to further treatment. When House is moved to a new ward in the hospital, he develops a close relationship with his new roommate, Alvie (guest star Lin-Manuel Miranda), and Lydia (guest star Franka Potente), a frequent visitor who helps House bend the rules. House asks Alvie to help him uncover incriminating information about Dr. Nolan that would allow him to blackmail his way out of the treatment center and convinces Lydia to loan him her car to sneak out a delusional patient in an attempt by House to undermine Dr. Nolan's course of treatment. But when devastating events ensue, House is humbled into reluctantly accepting help.

House returns home to Princeton where he continues to focus on his recovery. At the suggestion of Dr. Nolan, he steps down from his post as Head of Diagnostic Medicine because he attributes his unhappiness and subsequent addiction to the hospital. The team needs him more than ever when they are unable to diagnose a loud-mouthed video game creator who posts each new symptom on the internet and opts for treatments suggested by the online community rather than by the doctors. Meanwhile, as Foreman angles for House's old job, the pressure to solve the case creates tension in his relationship with Thirteen.

When a controversial African politician (guest star James Earl Jones) falls ill, he is brought to Princeton Plainsboro for treatment. The team struggles with whether to help a merciless dictator being subpoenaed for crimes against humanity in his country. Meanwhile, Wilson tries to make peace with a feuding neighbor, but House's prying exacerbates the problem.

A wealthy businessman brings his teenage son, who is suffering from inexplicable stomach pains, to Princeton Plainsboro and insists on having Dr. House handle the case. Although House still does not have his medical license, Cuddy allows him to take on the case under the watchful eye of Foreman. The father of the patient believes the karmic penalty of his financial success is that he is victim to personal tragedy, and that the answer to his son's medical mystery lies in a reverse of fate rather than medical treatment. Meanwhile, Foreman and Chase prepare to present a morbidity and mortality conference for the Dibala case.

The team takes on the case of a reckless police detective who has a family history of sudden heart failure that killed his father, grandfather and great-grandfather all at age 40. Though House is not keen on diagnosing the patient without any detectable symptoms, the team, urged by Cameron, attempts to identify his condition so the detective can live without fear of dying young. Meanwhile, Chase is haunted by his actions in the Dibala case, and House confronts some ghosts of his own.

After a wild night out, a teenage girl is brought to Princeton Plainsboro with severely swollen appendages. The team must work to diagnose the young girl, who is less than honest about what happened the night she fell ill, and as her condition worsens, becomes unable to distinguish fact from fiction. Meanwhile, Cuddy and Wilson attend a medical conference for pharmacology and public policy. House tags along, planning to use the outing as an opportunity to push a personal agenda, but things don't go as expected.

After House's medical license is reinstated, he reclaims his role as Head of Diagnostics in time to treat Hank Hardwick (guest star Troy Garity), an adult film star admitted to Princeton Plainsboro for pulsating eye pain. Meanwhile, Cuddy is reminded that the hospial is not conducive to healthy personal relationships, and House angles to form a dream team.

House and the team take on the case of James Sidas, an exceptionally brilliant physicist and author who traded his successful career for a job as a courier. For the ailing patient, intelligence is a miserable burden that has prompted depression and addiction, and this, coupled with his myriad unusual symptoms, nearly stumps the team. Meanwhile, the doctors at Princeton Plainsboro wrestle with strained personal relationships.

When an old friend and former patient (guest star Joshua Malina) of Wilson's exhibits paralysis in his right arm, Wilson puts himself on the case. House wagers Wilson that the patient's symptoms are attributed to new cancer cells. Wilson accepts even though he is reluctant to believe the cancer has returned. With the help of the team, Wilson works to diagnose the patient more optimistic results, but when things take a turn for the worse, Wilson must address his inability to separate patient from friend. Meanwhile, Cuddy seeks advice in her search for real estate.

When drug dealer Mickey (guest star Ethan Embry) mysteriously collapses while negotiating a sale, his partner-in-crime, Eddie (guest star Nick Chinlund), accompanies him to Princeton Plainsboro for treatment. But with a major deal pending, Mickey is not forthcoming with the necessary personal information the team needs to treat him. As Mickey's condition worsens, the team resorts to old-fashioned detective work to solve the case. Meanwhile, House and Wilson compete for the affection of a new neighbor, and Chase, Thirteen and Taub attempt to play a practical joke on Foreman.

The team takes on the case of Valerie, an attractive female executive experiencing random episodes of excruciating pain. House agrees to take the case based on Valerie's looks, and while treating her, the men on the team are charmed by Valerie's beauty and personality, with Thirteen looking beyond the superficial to try to discover a link to her illness. Meanwhile, House uncharacteristically attempts to alleviate his conscience by reaching out to a former medical school colleague he wronged.

House and the team rush to treat an ailing college football star in time for the patient to compete in NFL tryouts. But when the patient experiences an onslaught of varied and unusual symptoms, the team has trouble reaching a consensus on how to effectively treat him in time. Meanwhile, Foreman's brother Marcus (guest star Orlando Jones) makes a surprise visit to the hospital.

During a day in the life of Princeton Plainsboro's Dean of Medicine, Dr. Lisa Cuddy, the inner workings of the hospital are seen through her eyes. This day proves to be especially trying as Cuddy wrestles with myriad hospital issues and staff disputes that test her perseverance and skills as an administrator, all while juggling issues in her personal life.

House and the team take on the case of an avid blogger (guest star Laura Prepon) admitted with sudden bruising and bleeding. From her hospital bed, the patient blogs about her symptoms, doctors and prospective diagnoses to her dedicated band of followers and solicits their advice on a course of treatment. Such openness leads the team to contemplate the value of privacy, especially after House and Wilson uncover secrets from one another's past. Meanwhile, Chase is coaxed into testing out the dating scene.

The team takes on the case of a high school senior who inexplicably blacks out during a class field trip. While in the hospital, the patient repeatedly hallucinates. After exhausting myriad ineffective treatments for her mysterious ailments, House attempts one last controversial approach to diagnosing her: monitoring her cognitive patterns and looking for clues. Meanwhile, Taub airs his dirty laundry at work, and Wilson attempts to furnish his condo.

When a newborn disappears from the nursery, Princeton Plainsboro goes on lockdown, preventing anyone from entering, leaving or moving within the hospital. While House and his team members are trapped in various parts of the building, new insights about the team's personal histories, relationships and regrets surface. Episode directed by Hugh Laurie.

House and the team take on the case of Sir William, a "knight" in a closed-off community of men and women living according to the ideals of the High Renaissance. As the team searches the medieval village for environmental factors contributing to Sir William's rapidly deteriorating health, Thirteen and Sir William debate the acts that define honor and loyalty, especially in regard to the "queen" of the community, one of Sir William's most frequent visitors. Meanwhile, Wilson starts over with an ex (guest star Cynthia Watros).

House and the team take on the case of a woman, Julia (guest star Sarah Wayne Callies), who is in an open marriage and becomes ill during a date with her on-the-side boyfriend. As perplexing as the case is, Julia's happy and healthy, yet polygamous relationship is equally baffling to the team. Meanwhile, House tests Wilson's relationship with Sam (guest star Cynthia Watros).

The team takes on the case of an ailing groom-to-be who harbors undisclosed secrets from a previous relationship. As his fiancee (guest star Eva Amurri)And tries to get answers to her many questions, a frustrated team winnows down the possibilities. Meanwhile, House spends extracurricular time with his Princeton Plainsboro colleagues, performing a karaoke rendition of a Gladys Night And The Pips classic with Foreman and Chase.

During a session with Dr. Nolan (guest star Andre Braugher), House recounts the case of a woman who arrives at the Princeton Plainsboro emergency room with an unexplained illness and no recollection of who she is. While trying to solve the mystery of the woman's illness, House must also help her piece together her identity.

Cuddy, House and members of the team join forces with a search-and-rescue team to provide much-needed medical attention at the scene of an emergency in the Season Finale.

In the aftermath of last season's emotional finale in which House and Cuddy admitted they had feelings for each other, as Season Seven begins, they are exploring the ramifications of those feelings and attempting to make a real relationship work. Meanwhile, due to a colleague's illness, Princeton Plainsboro is left without a neurosurgeon on site, threatening the hospital's accreditation as a Level 1 Trauma Center. As the team attempts treatment to get their sick colleague back to work, they discover there is more to the illness than they originally suspected and turn to House for direction. Instead, House remains elusive, leaving the team on its own.

When Della (guest star Alyson Stoner), a seemingly healthy and active 14-year-old, suddenly collapses during a skateboarding exhibition, House and his team struggle to diagnose her condition and reassure her parents who already have to cope with their son's terminal illness. After her body rejects a donor lung, and with time running out to save her life, Della's family is left with little hope of securing a new donor and faced with a seemingly impossible decision regarding the fate of both children. Meanwhile, House tries to appease an elderly father and his son at the clinic, and House and Cuddy begin to face the challenges of taking their romantic relationship into the workplace.

When Alice (guest star Amy Irving), the author of a popular children's book series, inexplicably suffers from a seizure moments before an attempt to take her own life, the Princeton Plainsboro team faces the challenges of evaluating both her underlying medical conditions, as well as her unstable psychological state. Unable to diagnose Alice, House becomes particularly motivated, as he's a fan of her books, and is convinced that the key to unlocking the mysteries of Alice's condition lies in the pages of her most recent novel. Meanwhile, House takes Cuddy on a double date with Wilson and his girlfriend, Sam (guest star Cynthia Watros), and makes a discovery that proves that life imitates art as the couple continues to make compromises in order to make their relationship work.

When a patient named Margaret McPherson is admitted to Princeton Plainsboro after suffering severe and uncontrollable vomiting, House and the team make unexpected discoveries about her identity as they assess her symptoms. When the symptoms don't improve, the team looks to the patient's medical history to unearth more about her past. Meanwhile, House gives Chase's new hire a cold welcome, and a visit from House's massage therapist forces House and Cuddy to confront the reservations in their relationship.

After a newborn experiences inexplicable breathing problems and liver failure, House and the team look at the baby's mother, Abbey's (guest star Jennifer Grey), own medical history for possible clues. When the team makes a discovery about her newborn's health, Abbey is presented with a difficult decision that could potentially affect both her baby's health and her own. Meanwhile, following Cuddy's directive, House challenges Foreman and Taub to hire a female doctor to join the team. When Cuddy asks House to baby-sit her daughter, both House and Wilson learn a few hard lessons in parenting.

It's election season, and in the midst of a tight campaign, an incumbent New Jersey senator's campaign manager falls ill with liver failure and temporary paralysis. Cuddy pushes House to add a female doctor to his team by hiring brilliant third-year medical student Martha Masters (guest star Amber Tamblyn) in Thirteen's absence. House and the team are wary of the young doctor's lack of experience and medical perspective, but are forced to give their new by-the-book teammate a chance to prove herself. After the campaigning senator makes a surprising announcement, House and the team look to the candidate to find clues about the patient's condition. Meanwhile, Foreman learns that Taub has a past connection to Masters, and in an effort to save his patient's life, House must make a critical decision that may compromise his relationship with Cuddy.

After a 200-year-old medicine jar found on an off-shore shipwreck shatters in a teenage girl's palm, she is admitted to Princeton Plainsboro for symptoms closely linked to smallpox. When the Center for Disease Control's Dr. Dave Broda (guest star Dylan Baker) institutes a lockdown on the hospital and suspends House's team's ability to diagnose, Masters (guest star Amber Tamblyn) grows suspicious of Broda's motives and becomes convinced that the patient is suffering from a different disease. The girl's father soon experiences similar symptoms, and House is forced to make a precarious decision that puts his own life in jeopardy. Meanwhile, Wilson and Sam (guest star Cynthia Watros) comfort a 6-year-old chemotherapy patient who prompts them to examine their relationship.

Science and faith are called into question when a patient is admitted to the hospital following his reenactment of the Crucifixion. The patient, Ramon Silva, refuses to undergo the prescribed treatment, and the team learns that after his daughter's cancer was cured, he pledged an oath of self-sacrifice to God. With little time to save Ramon's life, the team struggles to understand his reasoning and seemingly extreme religious convictions, but eventually learn that faith is not an argument. Meanwhile, Taub questions his wife Rachel about her relationship with an infidelity support group member and the team attends a co-worker's wedding where Wilson's relationship with Sam (guest star Watros) takes an unexpected turn.

When a man (guest star Matthew Lillard) puts his life on the line to save a stranger who fell onto the subway tracks, he emerges from the dramatic scene miraculously unscathed but then suddenly collapses. Both the hospital and the town become captivated by the man's selfless deed, but as the team works to diagnose his symptoms, they discover that the hero's seemingly life-changing deed failed to break old habits. Meanwhile, House tries to avoid Cuddy's birthday dinner with her opinionated mother Arlene (guest star Candice Bergen), and Taub draws unexpected attention when his face graces billboards advertising the hospital. As Taub and his wife reignite a physical relationship, Masters' (guest star Amber Tamblyn) outside perspective helps him realize that it's time to take action on his crumbling marriage.

A teenage military trainee at a juvenile offender training camp suffers peculiar symptoms after enduring an intense training course, and mysteriously, his drill sergeant is soon admitted for similar symptoms. Unable to track down the cause of the shared illness, the team searches for clues in the trainee's family medical history, and Masters (guest star Tamblyn) and House reveal a unique bond between the sergeant and trainee. Meanwhile, when an indecent photo of Chase is posted on a social-networking site following three different romantic encounters, Chase is determined to find out which girl is trying to publicly disgrace him. Also, sensing Cuddy's stress over her daughter Rachel's enrollment at a prestigious preschool, House secretly prepares Rachel for observations and reveals a soft spot for the toddler.

Cuddy's mother, Arlene (guest star Candice Bergen), is admitted to Princeton Plainsboro after complaining about unusual symptoms, but stubborn Arlene insists that House be removed from the case, forcing House to come up with non-conventional -- and illegal -- means to treat his patient. House instructs his team to follow his lead, and they discover details in Arlene's personal life that she kept secret from Cuddy and her sister Lucinda (guest star Paula Marshall). Meanwhile, Taub's ex-wife, Rachel, puts him in contact with her brother who hires Taub to work a job on the side in exchange for much-needed income, which winds up taking a physical and emotional toll on him. Later, Cuddy places her trust in House to ensure that her mother receives the proper medical treatment, leading "by the book" medical student Masters to reevaluate her responsibility to practice within a code of ethics and to follow her boss' orders.

When a waitress with a perfect memory suffers temporary paralysis, her older sister visits her in the hospital, which triggers high stress levels and even more health complications. The patient's sharp memory proves detrimental when a grudge she's been holding against her sibling gets in the way of receiving proper medical treatment, and Masters discovers that patching a broken sisterhood may prove to be more complex than diagnosing the patient. Meanwhile, Foreman volunteers to help Taub prepare for a medical examination, and House, determined to help Wilson get back in the dating scene, discovers Wilson's secret new companion.

House participates in a school's Career Day and breaks a few rules by sharing explicit medical stories. Waiting outside the principal's office, he meets two fifth-grade students (guest stars Austin Michael Coleman and Haley Pullos) who assess House's relationship woes and try to help him understand how his selfish antics get in the way of showing Cuddy how he really feels.

A patient is admitted after breaking out in a severe rash triggered by caustic chemical exposure at his blue-collar job. As the team treats him, they discover that he has led his wife to believe that he is still maintaining his once-lucrative real estate career. Meanwhile, Cuddy is honored with an award and needs House to be at the charity event for support, but his attendance is threatened when his patient's battle to survive forces him to question his practice and his own happiness. Also, Chase and Masters teach each other a lesson in forging meaningful personal and professional relationships.

Tension reaches new heights when Cuddy faces sobering news that propels her to reevaluate her priorities. While House is distracted by his concern for Cuddy's well-being, the team treats a teenage patient whose worsening symptoms and suspicious body scars indicate more than just physical illness. Sensing the teen's troubled emotional and mental state, Taub turns to the patient's personal life for clues and uncovers disturbing home videos that could put the lives of his peers in danger. Meanwhile, Cuddy remains hopeful that House will be fully present when she needs him most, and a series of dreams, including a musical scene choreographed by Mia Michaels, provide glimpses into her life and her relationship with House.

A young professional champion bullfighter is admitted for treatment after being attacked by a bull. After conducting multiple inconclusive tests, the team enlists House's advice outside of the hospital while he attends to a few issues away from the case. Back in the hospital, the bullfighter's condition continues to worsen, but with disappearing symptoms and the patient's more frequent mini-seizures, the team's last option is risky open-heart surgery. Meanwhile, Masters develops a crush on their bullfighter patient much to Taub's surprise.

A young homeless man who is a former drug addict is found in a park showing signs of olfactory impairment and horrific scars and burn marks on his chest. With an uncertain identity and the patient's severely worsening conditions, the team looks to the patient's personal records and family history in order to understand his detachment. Meanwhile, Cuddy confides in Wilson and expresses her guilt for ending her relationship with House, and just as the team warms up to the patient, they discover a disturbing secret about the man whose life they saved.

Thirteen has been in prison for the past six months, but the real mystery for House is what she did to get there. When she exits the prison, Thirteen is surprised to find him waiting for her, and unaware of his plans for the two of them for the next few days. As House probes Thirteen for more information, intent on solving the puzzle of her disappearance and mysterious incarceration, they travel to an annual spud-gun competition. The two join forces to compete against House's much younger, overconfident rival, and along the journey uncover secrets and truths about each other. Meanwhile, at the hospital, the team treats a science teacher suffering from severe respiratory illness, and when the team inspects the patient's house for clues, they learn he's a hoarder. But upon a second visit to the house, they uncover something shocking among the many piles. Also, Taub tries to get back into the dating scene.

Masters faces a career crossroads on her last day as a medical student and struggles with the choice to continue on the path to become a surgeon or to accept the rare opportunity to join House's team officially. Meanwhile, the team treats a 16-year-old girl who inexplicably collapsed days before embarking on an ambitious sailing tour around the globe. Despite the patient's life-changing diagnosis, the patient's family insists on getting her back on the seas in time for her potentially record-breaking launch. But to the team's surprise, including House, Masters makes a bold decision regarding the patient's treatment.

After suffering partial paralysis while searching for a long-lost love, lottery winner Cyrus Harry (guest star Donal Logue) is brought to Princeton Plainsboro for treatment by House and the team. Cuddy's mother (guest star Bergen) threatens to sue the hospital for malpractice, jeopardizing both Cuddy and House's medical licenses. Chase and Foreman make a bet that tests each one in different ways.

When House and Wilson bet on a boxing match and disagree over the outcome, Wilson gives him exactly one day to pay up or prove him wrong. House presses the boxer for more information to help prove his case and ends up attempting to breathe new life into the losing fighter's career. Meanwhile, the team begins to suspect House may have another type of drug problem.

Thirteen's ex-con friend, Darrien (guest star Amy Landecker), arrives at Thirteen's apartment unannounced and in need of urgent medical attention. When she finds out that her friend has relapsed into drug use, Thirteen promises not to take her to the hospital where the cops could find her and instead turns to Chase in desperation. Meanwhile, House deals with devastating information, and Taub begins to come to terms with surprising news.

In the season finale well-known performance artist Afsoun Hamidi (guest star Aghdashloo) is admitted to the hospital, but when the team learns that her symptoms may have been self-inflicted as part of a documentary for her latest performance piece, they begin to question whether treatments are necessary and if they are unwittingly participating in the creation of a piece of her art. Meanwhile, a situation prompts House to do something that could change his relationship with Cuddy and Wilson permanently.

A year has passed since House (Hugh Laurie) crashed his car into Cuddy's (Lisa Edelstein) home, and we find House spending time behind bars at the East New Jersey Correctional Facility under the close watch of the prison warden (guest star Michael Par). When an antagonistic prison gang leader makes a serious threat, House solicits the help of a fellow inmate (guest star Jaleel White), but when another inmate's unusual medical symptoms spark his curiosity, House must come up with creative ways to treat the patient while navigating prison rules. House meets Dr. Jessica Adams (Odette Annable), a young, intelligent and bright-eyed clinic doctor, but when they are faced with a controversial opportunity to diagnose the patient's life-threatening illness, Adams is confronted with a choice to trust House and put her career on the line or play by the book.

A surprising visitor makes House an offer he can't refuse by giving him the opportunity to help the Princeton Plainsboro team treat a unique patient in order to save the life of an organ recipient being treated by Wilson. Although House finds himself back on familiar ground, he quickly realizes that much has changed since he left, and he is forced to work on the case with smart yet timid resident Dr. Chi Park (Charlyne Yi). After several inconclusive treatments and with time running out, House and Dr. Park are left with one last option to examine the patient's medical history that could compromise House's conditional agreement with the hospital. Meanwhile, House makes an effort to reconnect with Wilson despite a cold reception.

When Benjamin (guest star Wentworth Miller) suddenly collapses after making a rare and generous donation, House and Dr. Chi Park are convinced that his extreme altruistic behavior may indicate a deeper medical disorder. With no definitive explanation for Benjamin's loss of consciousness and unresponsiveness to treatment, House pushes just the right buttons to recruit former prison doctor Jessica Adams to volunteer her time and expertise to the case. Benjamin then makes a bold but life-threatening offer that could save another life, and the team must diagnose his disorder before he puts his own life on the line. Meanwhile, Adams and Park test each other's outlook on generosity and gratitude, and Thirteen's guilt conflicts with her pursuit of personal happiness.

A CEO (guest star Michael Nouri) falls mysteriously ill just days before he signs a contract that would relocate his company's entire labor force to China. House (Hugh Laurie) attempts to make an underhanded business transaction with his wealthy patient, but when the patient's condition worsens, the team must work around the clock to save his life. Meanwhile, Park (Charlyne Yi) prepares for her hearing with the Princeton Plainsboro Disciplinary Committee chaired by Foreman (Omar Epps), and Adams' (Odette Annable) outlook on her patient's business venture reveals her deeper feelings about loyalty.

A man (guest star Jamie Bamber) well-respected in his community suddenly collapses, and in the process of diagnosing his symptoms, the team discovers that the patient has been hiding dark and dishonest secrets about his personal and professional life. But when the patient openly confesses his wrongdoings to his family and community, he compromises his chances of receiving the proper medical treatment. Meanwhile, House will stop at nothing to manipulate Taub into taking a DNA test to prove he is the father of his two six-month-old daughters.

A teenage boy attempting to follow in his late father's footsteps as an entertainer is admitted to Princeton Plainsboro with partial paralysis. As the team searches for a bone marrow match, they uncover a disturbing family secret. Meanwhile, House looks for creative ways to remove his ankle monitor so that he can attend a boxing match in Atlantic City, and he treats a patient (guest star John Scurti) who is convinced he is suffering from diabetes. Also, Taub faces a tough decision when his ex-wife Rachel tells him that she wants to move across the country with their infant daughter.

The team learns that their 14-year-old patient (guest star Madison Davenport) is suffering from more than teen angst when her physical symptoms worsen. Despite Foreman's (Omar Epps) firm opposition, House (Hugh Laurie) becomes obsessed with solving a peculiar case of a deceased four-year-old patient, which gets him into serious trouble. Meanwhile, Park (Charlyne Yi) tries to get Chase (Jesse Spencer) to admit the reason behind his recent obsession with grooming.

A prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. The team's preliminary diagnosis is hyper-anxiety, but when Adams and Park investigate the patient's home and find a hidden arsenal of firearms, they uncover a more alarming and deep-seated psychological disorder. Also, Wilson becomes obsessed with proving that House is hiding something in his home, Park slowly comes out of her social shell and Foreman's lack of romantic relationships piques the interest of Taub and Chase.

An Alzheimer's patient visits Princeton Plainsboro as part of a hospital sanctioned drug trial, but when he inexplicably suffers from violent vomiting and an increasingly explosive temper, the team begins to unravel a deeper marriage conflict between the patient and his dutiful wife. Meanwhile, House and Foreman butt heads, and Wilson treats a patient who claims to be in a chaste marriage.

The team treats an underage and homeless female patient (guest star Bridgit Mendler), but when her symptoms worsen and call for an invasive surgery requiring adult consent, House and Adams argue over whether they should contact social services. The patient confesses that she ran away from home after struggling to take care of her mother, a recovering drug addict. But when her mother appears at her bedside, a more complicated relationship is revealed and the patient's mother must put the past aside and make the best decision for her daughter. Meanwhile, Taub has a difficult time connecting with his infant daughters and House threatens to exploit Foreman's relationship with a married woman (guest star Yaya DaCosta).

When a violent incident involving a patient has serious consequences, House and the team are placed under review by Dr. Walter Cofield (guest star Jeffrey Wright), Foreman's former mentor. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team's unconventional brand of collaboration against their ability to save lives.

Chase takes on a patient, Moira (guest star Julie Mond), who is a cloistered nun on the verge of making her life-changing vows, and through the treatment process, he and Moira form a unique connection that tests their faith and reason. But when Moira's condition worsens and requires a risky surgery, Chase's judgment is compromised. Meanwhile, House and Taub try to remain one step ahead of each other's pranks.

A marriage counselor collapses during a speaking engagement, but when he is put under close evaluation, the team notice changes in his behavior that conflict with his motivational message on the roles of men and women. Meanwhile, House and his Ukrainian "wife" Dominika (guest star Karolina Wydra) make a deal to convince Immigration that they are a happily married couple. Also, House decides to name a team leader.

House and the team battle to save a successful, independent blind man (guest star Michael B. Jordan) who is struck down by a mysterious illness, just prior to him asking for his girlfriend's hand in marriage. Meanwhile, House's mother (guest star Diane Baker) unexpectedly arrives at Princeton Plainsboro to inform him of her new beau (guest star Billy Connolly).

The team treats an Army veteran charged with treason after he leaked classified information. But the patient's life is put at risk when he refuses treatment unless he and his brother are given information about their late father, a war veteran, which raises questions about loyalty to one's family and country. Meanwhile, Adams suspects House may be sick, so she recruits Wilson and the other team members to plan an intervention and investigate his illness.

House and the team take on the case of a 22-year-old minor league hockey player who collapsed while coughing up blood after a fight on the ice. Meanwhile, House drops a bomb on Wilson, and Chase offers to help Park change her living arrangement.

House and the team take on the case of a man who starts tearing blood. Meanwhile, House is interviewing for a new favorite hooker, since his current favorite, Emily, has decided to get married and leave the business. Desperate for Emily "companionship," House teams up with his "wife" Dominika to sabotage Emily's budding relationship.

House and the team take on the case of a young boy who has violent dreams of being choked, and then wakes up but still can't take in air. Meanwhile, Park is having intimate dreams involving co-workers, which causes the team to question whether or not there's significance to what each of them dreams, and Dominika discovers a secret that could ruin her relationship with House.

When the team takes on the case of Emily, a six-year-old girl who has numerous preexisting health problems, they must work with her mother Elizabeth (guest star Jessica Collins), who happens to be a doctor herself, specializing in her daughter's condition. The team must also deal with the battles raging between Emily's mother and father who have conflicting views on how to handle her health issues. When searching the family's home for clues to Emily's illness, the team realizes that Elizabeth's determination to cure her daughter could be the very thing that is killing her. Meanwhile, House and Wilson take a little vacation.

In an episode directed by and guest-starring Peter Weller, the team takes on the case of Dr. Peter Treiber (guest star Jamie Elman), a pathologist at Princeton-Plainsboro Teaching Hospital who knows too much about the hospital staff to trust any of the physicians. The only person he does respect is House, who has mysteriously gone missing. With House in absentia, the team has to figure out how to treat Treiber while making him believe that House is calling all the shots.

The team takes on the case of Derrick (guest star Skylar Astin), a 19-year-old college student who had a mysterious nose bleed during cheerleading practice, and discovers that his health issues are likely both physiological and psychological. Possibly suffering from schizophrenia, Derrick claims to hear his deceased brother's voice in his head. Meanwhile, Wilson gets advice from former colleague Thirteen (guest star Olivia Wilde) and Foreman tries a different approach with House.

In the emotional series finale, directed by series creator and executive producer David Shore, treating a drug addict patient (guest star James LeGros, "Mildred Pierce") results in House examining his life, his future and his own personal demons.

A one-hour retrospective special that will look back at this groundbreaking, seminal series and feature interviews with the series' stars and producers, special original content and other surprises.