Adrian Monk (Tony Shalhoub) was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic and still-unsolved murder of his wife, Trudy, the devastated Monk becomes obsessive-compulsive. His psychological disorder has caused him to develop an abnormal fear of virtually everything: germs, heights, crowds... even milk. Monk's condition costs him his job, but he's back as a police consultant despite the unique challenges he encounters in his everyday life. These challenges lead Monk to hire a personal nurse, Sharona Fleming (Bitty Schram), who is always there to offer her assistance, even with the simplest of tasks (like organizing his sock drawer). Sharona is Monk's own "Girl Friday," an unlikely Dr. Watson to his Sherlock Holmes. Her less-than-subtle prodding keeps the "defective detective" on track in his investigations, as well as in his efforts to convince Captain Stottlemeyer (Ted Levine) to allow him to return to the force.
When Sharona returns to San Francisco to handle legal issues related to an uncle's death, Monk suspects foul play and finds himself torn between the differing styles of Sharona and Natalie. Bitty Schram guest stars.