Dr. Will Halstead (Nick Gehlfuss) has to balance the stress as the ER's supervising attending physician while exploring a budding romance with Dr. Natalie Manning (Torrey DeVitto), an emergency pediatrics resident. Rising star heart surgeon Dr. Connor Rhodes' (Colin Donnell) skills are put to the test with the arrival of a new, highly competitive cardiothoracic fellow, Dr. Ava Bekker (Norma Kuhling). Dr. Daniel Charles (Oliver Platt) recovers from the physical and psychological injuries of being shot, but remains the Sherlock Holmes of psychiatry. Dr. Sarah Reese (Rachel DiPillo) continues her psychiatry residency under Dr. Charles, despite new reservations in the wake of her mentor's assault. Former Navy flight surgeon Dr. Ethan Choi (Brian Tee) brings his battlefield skills to the front lines of Chicago's busiest ER, the go-to place for victims of the city's gun violence. Sharon Goodwin (S. Epatha Merkerson), the venerable head of Chicago Med, balances the pressure of keeping the city's largest hospital afloat while maintaining an atmosphere of quality care and compassion.
Dr. Charles and Dr. Manning disagree on how to handle a patient who they discover is poisoning herself. Dr. Rhodes throws some serious accusations at Dr. Bekker. Dr. Halstead has suspicions about Natalie's new boyfriend and Dr. Choi tends to Bernie.