Take New York City, add every horrifying beast, sci-fi freak, and fantasy faerie, shake thoroughly, and you've got Ugly Americans—the animated horror-comedy about a guy helping new citizens, both human and "other", adapt to life (and death) in the city.
In honor of Twayne's 10-year anniversary of running the D.O.I., Callie and the crew throw him a roast; before his first day as boss is up, Mark makes a management mistake so catastrophic that it almost destroys New York City.