New York Police Department detective Sara Pezzini (series star YANCY BUTLER) brandishes the Witchblade, an intelligent, symbiotic weapon of incredible power that has existed since prehistoric times. She has turned back time and resurrected her murdered partners, Danny Woo (series star WILL YUN LEE) and rookie Jake McCartey (series star DAVID CHOKACHI). But her nemesis, Ian Nottingham (series star ERIC ETEBARI), continues to pursue the source of Sara's strength. Sara relies on young historian Gabriel Bowman (series star JOHN HENSLEY) for help in understanding the Witchblade.
Sara and Danny Woo are once again in pursuit of the elusive mobster Tommy Gallo (recurring guest star CONRAD DUNN). As before, Gallo's henchman lures Sara into the museum where she first encounters the Witchblade, and it claims her as its chosen wielder. This time, however, things are different.