Now fully recovered, Alexander tasks Cardinal Sforza (Peter Sullivan) with instigating an "inquisition" among the Cardinals who were politicking against him when his life lay in the balance. With the "evidence" he needs, Alexander dismisses and banishes all the Cardinals he does not trust. But one of them - Cardinal Orsini (David Dencik) - does not leave quietly, forcing Alexander to handle it with his bare hands. Meanwhile, Catherina Sforza (Gina McKee) orders Rufio (Thure Lindhart) to seek support from the mercenary warlords of the Romagna families - Orsini, Vitelli and Colonna. Lucrezia (Holliday Grainger) is annoyed that her in-laws to be - the royal family of Naples - will not welcome her son Giovanni at court; plus she is realizing her feelings for Cesare (Francois Arnaud) are becoming more than sexual than sisterly.