This application contains information on common HIV treatment regimens and interactions with opioids, Medication Assisted Treatment, Recreational Substances, and Reversal medications. This App contains 4 tabs – HIV-Opioid, MAT, Reversal Medication Interactions, HIV-Recreational Drug Interactions, Drug Metabolism, and Common Web Resources. Data from this App was developed using DHHS HIV Guideline tables and the Northeast Caribbean AETC Pocket Guide on Interactions with HIV and Narcotics and Recreational Drugs.