Breakpoint MIC, calcolo mic ,

Massimiliano Vitale

Mayelana nalolu hlelo lokusebenza

Ukukhetha umuthi olwa namagciwane ongawusebenzisa uma kungenzeka ungenwe yigciwane kungenye yemisebenzi enzima nodingeka kakhulu kudokotela. Ukwazi ngezimpawu ze-antiotic kanye nekhono lokwenza ukuxilongwa okulungile kubalulekile.
I-MIC ephansi kakhulu (ubuncane be-inhibitory okuhlushwa) ayihlali ikhomba i-antibiotic ephumelela kakhulu, njengoba isilinganiso phakathi kokuqhekeka (BP) ne-MIC sibikezela kakhulu, isb. I-antibiotic ene-MIC = 0.5 ne-BP = 1 (BP / isilinganiso I-MIC = 2) izocatshangelwa ukuthi ayisebenzi kahle ku-vitro kuneyodwa ene-MIC = 2 ne-BP = 32 (isilinganiso = 16).
Ukusebenza kwekhambi lokwelapha elwa namagciwane kushukunyiswa izici eziningi ezifana nezinga lokuzwela kwe-microorganism, i-pharmacokinetics ye-antibiotic (isb. Ukumuncwa kwe-ADME, i-metabolism, ukusatshalaliswa, i-excretion), i-pharmacodynamics (isb. Ukusebenzisana phakathi kwe-microorganism ne-antibiotic) kanye Izici ezihlobene nesiguli ezinjenge degree lakhe lokugonywa, indawo ukutheleleka kanye nokuba khona kokufakwa kokufakelwa. \ n \ n Noma kunjalo, ukuzwela kwe-vitro kuyindawo elula kakhulu yokulinganisa futhi izifundo zomtholampilo zikhombisile ukubaluleka kwemitholampilo kwemiphumela yokuzwela ivezwe ku-MIC. Ngakho-ke isidingo sovivinyo olunembile noluthembekile lungaphindwa kuphela; uhlobo lokwelashwa lungenye yezinto ezimbalwa ezingashintshwa ukwenza ngcono ukuthuthuka kwesiguli ngokungafani nobudala bakhe, ukubumbana okuthile, uhlobo lokutheleleka. Kwezifo ezimbi kakhulu, ezifweni ezitholwa endaweni kumasythi lapho i-antibiotic ingena khona ngobunzima nasezigulini ezigonywa, umphumela ovezwe nezigaba S, I, R unenani elilinganiselwe lokulinganisa. Kulezi zimo, umphumela wokuzwela we-quantitivity ubaluleke kakhulu njengoba kucacile ukuthi kunomehluko ekuphenduleni komtholampilo phakathi kwe-antibiotic ene-MIC ye-0,06 µg / ml kanye ne-MIC ye-1 µg / ml lapho ukuhlukana kokuzwela kubona bobabili "1µg / ml. Nginikezela lolu hlelo lokusebenza ekuqasheni komkami uMarina. Ulwazi kumele lwedluliselwe mahhala uma lungasindisa izimpilo.

Yini entsha

api 35