100+
Okudawunilodiwe
Isilinganiselwa sokuqukethwe
Wonke umuntu
Isithombe sesithombe-skrini
Isithombe sesithombe-skrini
Isithombe sesithombe-skrini
Isithombe sesithombe-skrini
Isithombe sesithombe-skrini
Isithombe sesithombe-skrini

Mayelana nalolu hlelo lokusebenza

Uhlelo lokusebenza lwe-BRCAplus luhlose kodokotela abafuna ukuthola okuningi mayelana nokunengqondo, ukukhombisa kanye nokwenza umsebenzi wokuxilongwa kwe-BRCA. Umqondo kanye nokusebenza kohlelo lokusebenza kubhekela izidingo ezimbili ezibalulekile:

-> Ukufinyelela okusheshayo kwezihloko ezingokoqobo.
-> Ukuxhumana nezinsizakusebenza ezibalulekile zemfundo kanye nokuhlolwa.

Kulokhu, i-BRCAplus inikeza ulwazi oluhlelwe kahle olususelwa kubufakazi bamanje, izincomo, izinkombandlela nemithetho.

Ukubuka ukubuka okungcono uzothola:

- Izifingqo eziholayo.
- Ukugqamisa ukwamukelwa okungcono.
- Ihluzo eziningi ngomfanekiso.

Izidingo zokuxilongwa kwe-BRCA zokuhlelela ukwelashwa kuqhathaniswa nokuhlola ubungozi emndenini kanye nenqubo yokuhlaziywa kwezakhi zofuzo ezinikezwa ngesinyathelo ngesinyathelo kusukela ekukhetheni kwezinto eziyisampula kokutholakele. Lokhu kufaka imininingwane:

- ukuqala ukuxilongwa kokuhlelela ukwelashwa,
- impahla eyisampula,
- Ukuhlaziywa kofuzo kusetshenziswa i-NGS,
- ye-biioinformatics kanye nokuhunyushwa kwedatha,
- ngezigaba zokuhluka kwe-BRCA,
- ekutholeni izakhi zofuzo,
- imfundo yezakhi zofuzo.


Izifo ezengeziwe zamathumbu zingabonakala ngezakhi zofuzo futhi ziphathwe ngendlela eqondiwe. Inani lezinhlobo ezithintekayo ezinomdlavuza lihlala likhula njalo. Izinhlobo ze-BRCA zibaluleke kakhulu ekuhleleni kokulashwa nge-PARP inhibitors (1-3)
Uhlelo lokusebenza lwazisa ngalo:

-> Yimiphi imisebenzi nezinhlaka ezinezinhlobo ze-BRCA1 / 2,
-> kwenzeka kanjani ukusweleka kokuphinda kwenziwe kabusha (i-HRD),
-> okuvela kuwo amaphuzu okuqala kokwelashwa kuwo.

Uma ungathanda ukuthola ukuthi izinhlobo ze-germ-line noma ezinye ze-BRCA eziguqulwe kanjani nokuthi zisebenza kanjani, chofoza ngqo kusihloko esihambelanayo.

Ukutholwa kokuhluka kwe-pathogenic kwe-BRCA1 / 2 kusunguliwe ukuze kuhlolwe ubungozi kanye nokuhlelela ukwelashwa. Kepha iyini i-phenotype ye-BRCAness? Uhlelo lokusebenza le-BRCAplus linikeza izimpendulo.
Lesinye isigaba sinikelwe inqubo yokusebenza kwe-PARP inhibition. Amagama agqamile: ubugebenga bokwenziwa kanye nesicupho sePARP.

Ukuhlela izihloko zokwelapha. Uhlelo lokusebenza liyachaza:

-> yiziphi izincomo zamanje ezitholakalayo
-> Izimo lapho ama-PARP inhibitors angasetshenziswa kuzinkomba ezifanele,
-> inikeza isifinyezo sezifundo nge-PARP inhibitor olaparib.




Okuqukethwe kwalolu hlelo lokusebenza kudalwe yi-AstraZeneca ne-MSD ngosizo lochwepheshe emikhakheni yabo.

iziqinisekiso
1. https://cancergenome.nih.gov
2. Isikhombisi-ndlela se-Interdisciplinary S3 sokutholwa kokuqala, ukuxilongwa, ukwelashwa kanye nokulandelwa kwenguqulo yomdlavuza webele 4.3 - _February 2020 AWMF rejista nenombolo: 032-045OL, kokugcina ukufinyelela ngo-15.5.2020
Iseluleko se-1.S3 sokuxilonga, ukwelashwa nokunakekelwa kokulimala kwama-ovarian tumor, inguqulo 3.0- Januwari 2019, inombolo yerejista ye-AWMF: 032 / 035OL, ukufinyelela kokugcina 15.5.2020
Kubuyekezwe ngo-
Mey 28, 2024

Ukuphepha kwedatha

Ukuphepha kuqala ngokuqonda ukuthi onjiniyela baqoqa futhi babelane kanjani ngedatha yakho. Ubumfihlo bedatha nezinqubo zokuphepha zingahluka kuye ngokusebenzisa kwakho, isifunda, nobudala. Unjiniyela unikeze lolu lwazi futhi angalubuyekeza ngokuhamba kwesikhathi.
Le app ingabelana ngalezi zinhlobo zedatha nezinkampani ezingahlobene ngqo
Umsebenzi wohlelo lokusebenza
Ayikho idatha eqoqiwe
Funda kabanzi mayelana nokuthi onjiniyela bakuveza kanjani ukuqoqwa
Idatha ibetheliwe lapho ithunyelwa
Ungacela ukuthi leyo datha isulwe