Patient Zero: Virus Survival

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Everyone
100+
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Everyone
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About this game

Have you ever wondered what happens inside the body when an uninvited guest enters? PATIENT ZERO: VIRUS SURVIVAL is a fast-paced survival roguelite and hardcore virus simulator where you play as the ultimate pathogen. Control a deadly infection, mutate your DNA, and conquer the host in this action-packed survival game. Your goal is to survive the relentless immune system in the ultimate roguelike survival experience!

🧬 PRIMORDIAL CHAOS: THE INFECTION STORY
Born in the darkest corners of a forgotten lab (Project EvoCell), you are the result of forbidden RNA experiments. Now, you are free to begin your infection game journey. To survive the harsh environment of the human body in this hardcore action roguelite, you must consume healthy cells and turn the host's energy into your own instruments of destruction.

🦠 REAL-TIME EVOLUTION & MUTATION
Forget static abilities. Your power grows every second in true roguelike fashion. Every defeated immune cell is a step toward a new mutation:

Viral Nova: Wipe out entire armies of antibodies with powerful energy bursts.

Toxic Trail: Leave acidic puddles that melt enemy membranes in seconds.

RNA Spikes: Your long-range weapon. These sniper projectiles pierce through cells.

Vampirism: Consume enemies to instantly repair your damaged code.

Viral Spores: Create microscopic time bombs that orbit around you.

🗺️ 7 BIOMES & AN ANATOMICAL ATLAS OF TERROR
Your survival game mission spans 7 highly detailed Acts:

Breath of Death: Fight through the Alveoli and Bronchi, where every breath is a storm.

The Bloody Path: Arteries will meet you with a frantic rhythm.

Labyrinths of the Mind: Face the electrical discharges of neurons in the Brain's Cortex.

Deep Infiltration: Destroy the filters of the Liver, Spleen, and Intestines to deliver the final blow to the Heart!

🛡️ BULLET HELL COMBAT & EPIC BOSSES
The human body is a fortress. Face 21 types of enemies and 14 unique bosses. Dodge intense fast-paced bullet hell combat and defeat the generals of the immune system: from the lightning-fast Leukocyte Prime to The Eternal Pulse. Beware: upon taking critical damage, bosses enter a deadly ENRAGED mode!

⏱️ 5-MINUTE SURVIVAL RUNS & THE LAB
Each run lasts exactly 5 minutes—perfect for a mobile survival game. Death is not the end of your roguelite loop, but a chance to fix your genetic code. Collect Mutation Points (MP) and upgrade your skill trees in the Lab: boost HP, damage, and regeneration. Return stronger for your next infection run.

Perfect for fans of roguelike survival games, virus simulators, and fast-paced bullet hell combat.

✨ KEY FEATURES:
• Action Roguelike: Endless skill combinations make every run unique.
• Hardcore Bullet Hell: 5-minute sessions challenge your reaction. No mercy—pure skill.
• Virus Simulator: Scientifically accurate terms mixed with a stunning art style.
• Play Offline: Enjoy this hardcore offline survival game without internet or Wi-Fi, anywhere, anytime!

Can you mutate fast enough to avoid eradication? Or will you become the biological error that stops the heart of humanity itself?

Infect. Destroy. Evolve.
Install PATIENT ZERO right now and begin your invasion! 🚀🧬👾🧪
Updated on
Jun 21, 2026

Data safety

Safety starts with understanding how developers collect and share your data. Data privacy and security practices may vary based on your use, region, and age. The developer provided this information and may update it over time.
This app may share these data types with third parties
App info and performance and Device or other IDs
No data collected
Learn more about how developers declare collection
Data is encrypted in transit
Data can’t be deleted

What’s new

• Action from the start: Enemies now spawn immediately at the beginning of the level.
• New interactive tutorial for the DNA Lab: learn how to evolve Viral Spores and upgrade your virus!
• Minor bug fixes and balance improvements.