Patient Zero: Plague game

Contains adsIn-app purchases
4.3
11.2K reviews
1M+
Downloads
Content rating
Teen
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image
Screenshot image

About this game

"Patient Zero" is a terrifyingly realistic virus simulator that combines strategic gameplay with a true-to-life global crisis. This is not just another virus game—it's a fully immersive pathogen game where every decision can alter the fate of humanity.

Your virus infection has just begun with "Patient Zero." Now it's your mission to develop a deadly plague and adapt against everything humanity throws at you. This is the ultimate test of survival, cunning, and biology in one of the most intense pandemic games ever made.

Features:
● Hyper-realistic, highly detailed world—experience the depth of a true virus simulation
● Flash controls and intuitive interface to guide you through global domination
● 15 unique types of diseases—each one mutates differently in this complex disease game
● Every country on Earth is available for infection—from major cities to remote islands
● Hundreds of traits to evolve, thousands of world events to respond to
● Built-in tutorials and help system for new players of biology games or infecting games

Will you save the world or watch it fall? Become the ultimate bio-strategist in this pandemic plague game. Whether you’re stopping the outbreak or accelerating the virus infection, the fate of the planet is in your hands.

If you love virus infection games, pandemic simulations, or strategic infecting games, this is the virus game you’ve been waiting for. Adapt. Survive. Infect.

Download Patient Zero now – the most addictive and realistic pandemic and disease game experience on mobile!
Updated on
Dec 13, 2025
Available on
Android, Windows*
*Powered by Intel® technology

Data safety

Safety starts with understanding how developers collect and share your data. Data privacy and security practices may vary based on your use, region, and age. The developer provided this information and may update it over time.
This app may share these data types with third parties
Location, Personal info and 2 others
No data collected
Learn more about how developers declare collection
Data isn’t encrypted
Data can’t be deleted

Ratings and reviews

4.3
10.3K reviews
Levias Wolfe
August 10, 2025
I have completed the bacteria strain four times and it will not let you progress to the next pathogen, as others have said. I also have experienced the bug of speeding up immediately shutting off. You have to fully close the game for it to start working again. It is a pretty decent game, but these bugs need to be fixed. I would not make any purchases.
173 people found this review helpful
Did you find this helpful?
Tabitha Applebee
October 29, 2025
Genuinely enjoy the game, it's great, but after the first reset the ads become unbearable. Want to level up? Ad. Want to see the spread map? Ad. Want to collect revenue? Another. Ad. It's greedy and ridiculous. No one would pay $10-$15 to buy the game, but devs expect us to pay that to remove ads. I'm done with games like this. What a way to ruin a great game.
34 people found this review helpful
Did you find this helpful?
Brightika, Inc.
November 25, 2025
We hear you! Ads are a necessary part of keeping the game running and free to play. We appreciate your understanding and will keep reviewing our ad settings.
Levi VanDenBerg
December 12, 2025
Was great until the intrusive ads started. For the first few evolutions you dont have to deal with any pop-up non optional ads. You could watch ads to boost productions but you didn't need to. That balance felt really nice and I was fully invested. After the 3rd evolution popup ads began. Basically every time you click anything - boom - ad. And they're always unnecessarily difficult to close. Click a teeny tiny X 5 seperate times to close a "skippable" ad. Miss the x and it sends you here.
5 people found this review helpful
Did you find this helpful?

What’s new

A new pathogen has been added