Topics in Bone Biology

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Latest release: March 9, 2013
Series
7
Books
Engineering of Functional Skeletal Tissues
Book 3·Mar 2007
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The science of bone replacement has greatly advanced in recent decades, but replacing bone with bone tissue rather than with metallic components remains in early development. The current volume, third in the series Topics in Bone Biology, deals with problems inherent in inducing the body cells to accomplish bone tissue repair, to degrade devices introduced to provide initial mechanical support, and to attract and stimulate bone f- mation. It is therefore logical that Chapter 1, by Hicok and Hedrick, deals with stem cells, i. e. , pluripotential cells that may differentiate into cartilage and bone cells. The chapter begins with a description of how stem cells may be harvested; the limitations of autologous, embryonic, and adult stem cells; and the need to expand the harvested cells in culture. The authors then discuss the in? uences of the body environment on implanted cells and on the scaffolds that need to be introduced. They emphasize the need for adequate oxygenation and for rapid integration with the vascular system of the host/patient. Stem-cell-engineered cartilage is discussed at some length, along with the need for stem-cell-engineered ligaments and tendons. The chapter concludes with an analysis of what needs to be learned to make stem-cell-engineered bone tissue a reality. In Chapter 2, Gerstenfeld and colleagues review osteogenic growth factors and cytokines, soluble proteins that regulate postnatal bone repair. These molecules are of importance because many are targets of efforts to promote therapeutic bone healing and repair.
Bone and Osteoarthritis
Book 4·Sep 2007
5.0
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Orthopedics and rheumatology, while separate specialties, have become close conceptually because advances in bone and joint biology enable practitioners to approach clinical problems comprehensively. This is especially true for the bench and translational scientists. Recently, there has been renewed interest in the role played by bone in the development of osteoarthritis, including targeting bone as a potential therapeutic approach.

The molecular and cellular approaches toward the relationship of joint and bone problems distinguish this from other books on osteoarthritis or skeletal medicine. Emphasis on genetics and on newer viewpoints and approaches, exemplified by the possible effect of subchondral bone on osteoarthritis, gives a wider viewpoint to the reader and may make possible novel approaches to solving a clinical problem. The book will therefore also interest experienced specialists, thereby broadening readership. Authors are internationally recognized experts in their field.

Topics discussed include the role of bone in osteoarthritis, ranging from basic cell and molecular biology to genetics and biomechanics. How this information may be used for new treatment approaches will also be covered.

This book, intended for students, researchers and clinicians, provides information that enables the novice to become oriented and the practitioner to update knowledge. No other book combines information on the relationship of bone to the development of osteoarthritis, or treats the pathophysiology of joints in the same way. This volume, like the others in Topics in Bone Biology series, encompasses aspects of many specialties, including rheumatology, orthopedics, endocrinology, oncology, dentistry, geriatrics, nursing and chiropractic medicine.

Bone-Metabolic Functions and Modulators
Book 7·Jun 2012
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Recent research, which Bone- Metabolic Function and Modulators expands on, has added new support to the idea that bone not only serves as a support system, but also functions as an integrating organ, with a significant regulatory role for lipid and energy metabolism. Links between physical activity and the skeleton are also becoming increasingly clear. This fully illustrated volume contains up-to-date information on the metabolic role of the skeleton and what this can mean for the treatment of metabolic as well as skeletal and auditory diseases.

Bone- Metabolic Function and Modulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocrinologists, internists, dentists, nurse practitioners, medical and dental residents and physiotherapists as well as students of the musculoskeletal system.

Bone- Metabolic Function and Modulators is the seventh volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson.

Other titles in this series:-

Bone Formation

Bone Resorption

Engineering of Functional Skeletal Tissues

Bone and Osteoarthritis

Bone and Cancer

Bone and Development

Bone- Metabolic Function and Modulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocrinologists, internists, dentists, nurse practitioners, medical and dental residents and physiotherapists as well as students of the musculoskeletal system.

Bone- Metabolic Function and Modulators is the seventh volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson.

Other titles in this series:-

Bone Formation

Bone Resorption

Engineering of Functional Skeletal Tissues

Bone and Osteoarthritis

Bone and Cancer

Bone and Development

Bone- Metabolic Function and Modulators is of particular interest to clinician scientists, clinical and basic bone researchers, orthopedists, endocrinologists, internists, dentists, nurse practitioners, medical and dental residents and physiotherapists as well as students of the musculoskeletal system.

Bone- Metabolic Function and Modulators is the seventh volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson.

Other titles in this series:-

Bone Formation

Bone Resorption

Engineering of Functional Skeletal Tissues

Bone and Osteoarthritis

Bone and Cancer

Bone and Development