This suspenseful and twist-filled thriller begins after a married accountant, Grant (Leo Grillo), is caught in a roadside motel having an affair with a beautiful seductress named Marissa (Katherine Heigl) that he met in a Vegas casino. When her enraged boyfriend, Joey, (Tom Sizemore) busts in on them, Grant inadvertently kills him. Faced with the harsh reality of betrayal and murder, Grant and Marissa are forced into the desert to dispose of the dead body.
On the lone deserted Zyzzyx Road they think of a plan to bury the corpse. However, much to their surprise the body is missing. Grant questions reality as seemingly impossible things begin to happen. Suffering from fear, fatigue and a gaping head wound, Grant begins to question what the realities of his life are. Is Marissa as innocent as I thought or have I been set-up? Is Joey really dead or did I imagine killing him?