City Rats tells the stories of eight people going through their own personal crises, whose lives are connected in some way. In one scenario, a man prepares to throw himself off a building when he spots a fellow suicidal on an adjacent rooftop. United by their suffering, the pair realise that there must be another way out. A down-on-his-luck artist finds inspiration in the unlikeliest of places--the prostitute living next door--but winds up paying a high price for her cooperation. Elsewhere, a gay man leads his deaf-mute brother--who also happens to be gay--through the streets of Soho in an effort to help him lose his virginity. Danny Dyer stars as a man whose shadowy past comes back to haunt him when the mother of an old friend approaches him for help in finding her missing son.