Male Nurse Greg Focker (Ben Stiller) is poised to propose to his girlfriend Pam (Teri Polo) during a weekend stay at her parents' home. But here's the catch...he needs to ask her father first. Alas, the fur flies as Jack Byrnes, Pam's cat-crazy, ex-CIA father, played hysterically by Academy Award winner Robert De Niro, takes an immediate dislike to her less-than-truthful beau.