While protecting his village from a rampaging boar-god, the young warrior Ashitaka becomes afflicted with a deadly curse. To find the cure that will save his life, he journeys deep into sacred depths of the Great Forest Spirit's realm where he meets San (Princess Mononoke), a girl raised by wolves. It's not long before Ashitaka is caught in the middle of a battle between iron-ore prospecting humans and the forest dwellers. He must summon the spirit-powers and all his courage to stop man and nature from destroying each other.