"Nothing wrong with a man taking pleasure in his work. I won't deny my own personal desire to turn each sin against the sinner." Gluttony, greed, sloth, envy, wrath, pride, lust - everyone has a sin. For detectives William Somerset and David Mills they live among these sins, everyday, a crumbling city of crime all around them. But nothing can prepare the partners for the killings they are about to experience, all of which begins when they find a morbidly obese man who has died from the forced ingestion of spaghetti. What starts as one bizarre crime turns into a case of serial murders as a predator named John Doe begins to execute victims by paying homage to the "deadly sin" they represent.