Supernova chronicles the search and rescue patrol of a deep space medical ship and its six-member crew. When their vessel, the Nightingale 229, answers an emergency distress signal from a comet mining operation in a distant galaxy, the crew soon finds itself in danger from mysterious young man they rescue, the alien artifact he's smuggled aboard, and the gravitational pull of a giant star about to go supernova -- the most massive explosion in the universe.