Charlie Sheen is "Charlie," a successful therapist who thrives on the chaos in his life while still battling his own anger issues. Charlie's colorful cast of patients includes his weekly regulars and the group of inmates he counsels pro bono at a state prison. His life is further complicated by his relationships with women, including his own therapist and best friend (Selma Blair), his ex- wife (Shawnee Smith), his 13-year-old daughter (Daniela Bobadilla) and his father (Martin Sheen).