When one of Grey Sloan's own lands in the hospital, Bailey tries to figure out what happened while the rest of the doctors jump in to help. Meredith juggles huge secrets that affect her relationships with Alex and Maggie. While Richard helps Jo with a big decision, April and Catherine clash over the new baby.
Meredith considers her loyalties, while Alex deals with the repercussions of his actions. Newlyweds Amelia and Owen host a dinner party with unlikely guests, and Jackson proposes an arrangement to help April through her recovery.
A car crash at a funeral brings a bickering family into the hospital. Back from New York, Arizona ends up caught between Alex and Andrew. While Ben takes on a new parenting role, Amelia helps Meredith and Maggie through a problem.
Alex tries to do the right thing but still can't catch a break. Jackson and April adjust to their new normal with the baby. While Meredith and Nathan establish what's going on between them, Amelia questions the state of her relationship with Owen.
Meredith and Bailey are at odds when both of their patients need a liver transplant. Elsewhere, Owen seeks help from the other doctors when he is charged with babysitting baby Harriet for the day, and Amelia struggles with telling Owen some important news.
A familiar face returns to Grey Sloan, throwing many of the doctors for a loop. With Catherine putting on the pressure, Bailey has to make a decision about Alex, while a tough ER case makes Amelia's bad day even worse.
The arrival of a new consultant puts the doctors on edge, especially once she starts stepping on toes in the OR. Meanwhile, Amelia and Owen bring their personal problems into the hospital, while April explores uncharted territory.
Believing he is going to jail tomorrow, Alex makes a big decision about his future. While the hospital is overrun with victims of a building collapse, Richard demands answers from Bailey about Eliza's presence at Grey Sloan.
Maggie gets a surprise visit from her mother at the hospital. Bailey has to make a difficult decision when one of the attendings refuses to work with Eliza, and Stephanie gets caught up in Owen and Amelia's personal drama.
The residents are excited for Eliza's next phase of teaching, but they spend the day caught between the warring attendings. Meanwhile, April has a challenging first day in her new role at the hospital.
Richard, Jackson, April, and Catherine tackle a grueling trauma case intensified by hospital politics. Amelia finally faces her feelings about Owen, and Meredith gets caught between Nathan and Alex over a patient.
Maggie's mother returns to Grey Sloan, but Maggie is still in the dark as to why she's really there. Owen and Amelia hash out their problems as they work a trauma case together, and Bailey tries to mend her relationship with Richard.
April and Andrew consult with a fiery patient who has a giant, inoperable heart tumor. Meanwhile, Alex and Eliza are at odds over the treatment of a young patient, and Stephanie and Ben make decisions that could affect their careers.
The doctors of Grey Sloan encounter a difficult case involving a dangerous patient. Meanwhile, Owen receives life-changing news that pushes Amelia to step up to support him, and Alex attends a medical conference after making a shocking discovery.
Seattle Grace Hospital springs into action to save the lives of two young girls whose powerful story forces some of the doctors to revisit the effects of bullying on their own pasts. Meanwhile, Meredith adjusts to changes at home with her new roommates while Bailey continues to fight for the Chief of Surgery position.
The pressure is on as a determined Bailey tackles her first day as Chief; meanwhile, April's marriage is in jeopardy and she finds herself unable to address her problems; Meredith struggles to juggle all her responsibilities and Amelia works to define her relationship with Owen.
Maggie reevaluates her life choices after receiving an invitation to her ex-boyfriend's wedding; Richard questions Bailey's loyalty, and Jo confides in Stephanie about a secret she's been keeping from Alex. Meanwhile, Alex struggles with making a difficult decision that will affect the lives of newborn twins.
In the midst of the sisters' dinner party, Maggie ditches her cooking duties to rush to the hospital. Meanwhile, April steps in to help cook as an attempt to avoid Jackson, and Arizona nervously waits to find out more about Callie's new girlfriend.
Grey Sloan Memorial welcomes a new transfer resident, and also a patient who's the topic of conversation after accidently sending his sex tape to his entire congregation. Meanwhile, Richard wrestles with how to progress his relationship with Maggie when an old friend visits the hospital, and April brings in a case of a young boy from the Middle East.
The team of doctors work on a high stakes case of a long time patient, adding additional pressure to an already tense environment. Meanwhile, Bailey wants Ben to kick out their new roommate, and Arizona is eager to get back into the dating world with a new wingman.
As the rumor mill around the hospital continues to spiral out of control, Grey Sloan Memorial is flooded with injured firefighters from a nearby wildfire. Maggie struggles to keep things with Andrew professional at work; meanwhile, Jo questions Alex's priorities.
As the hospital deals with Meredith's trauma, Callie and Maggie perform a risky, experimental surgery on Alex's 15-year-old patient against his professional opinion. Meanwhile, Owen and Nathan are still at odds with each other, and Maggie and Andrew's relationship continues to develop.
The evolution of April and Jackson's relationship is revealed through a series of flashbacks dating back to when they first met. Simultaneously, we follow the years-long progress of one of Jackson's patients.
A patient from Meredith’s very first surgery as an intern is readmitted to Grey Sloan Memorial with a new aneurysm, and Amelia takes her case. Meanwhile, Maggie suspects that Richard knows about her relationship with Andrew.
The Grey Sloan doctors travel to a military hospital to perform a risky surgery on a veteran with an advanced tumor. Meanwhile, Andrew is tired of being Maggie's worst kept secret; Ben makes an impulsive surgical decision; and a team of cheerleaders wreak havoc in the ER.
Richard throws everyone for a loop when he switches the resident and attending pairings, and Arizona takes a huge risk on a woman who is pregnant with quadruplets. Meanwhile, April is faced with a difficult decision.
Jackson learns about April's pregnancy, while Alex and the team of doctors handles an hours-long, triple-organ transplant surgery. Meredith considers dating again, and Andrew insists on not receiving special treatment after he and Maggie go public.
Meredith takes a step forward with Will but quickly regrets it, while Maggie senses a disconnection with Andrew. Meanwhile, Amelia reevaluates her relationship with Owen, and Catherine comes to town and shakes things up with April and Jackson.
Meredith goes on an ambulance ride with Owen and Nathan to pick up a heart for a transplant patient. Musician & MS patient Kyle Diaz is admitted to Grey Sloan Memorial with a tremor in his hand. Meanwhile, Catherine continues to insert herself into Jackson and April's business against Richard's wishes.
After a missing child forces the hospital into lockdown, Ben decides to operate on a pregnant mother without the proper surgical equipment. Miranda, as Chief, is faced with the repercussions of the event and whether or not Ben's actions were justified.
Miranda continues to deal with the aftermath of Ben's reckless decisions and forms an advisory committee to recommend proper disciplinary action. Meanwhile, April and Jackson try to put their differences aside for the sake of their baby, and Arizona makes a decision that could affect her relationship with Callie forever.
Stephanie's relationship to Kyle becomes complicated. Meanwhile, Meredith encourages Amelia and Owen to choose to be a real couple. Arizona and Callie are at odds and put their friends in the middle of an uncomfortable situation.
Callie and Arizona are at odds over Sofia's future, and Stephanie questions the status of her relationship with Kyle. Meanwhile, Alex and April work on a pregnant teen that is readmitted to Grey Sloan Memorial.
Meredith and Maggie support Amelia on an important day. Jo reveals she has been keeping secrets from Alex, while Arizona and Callie deal with the impact of their custody arrangement. Meanwhile, Ben leaps into action to help a friend.
On the season eleven premiere, with Cristina gone, a new doctor, Maggie Pierce, making the rounds, and Derek wanting to move to Washington DC, Meredith struggles to regain a sense of normalcy both at home and in the hospital. Meanwhile, Callie and Arizona come to a decision about surrogacy, Amelia overhears a big secret, Bailey realizes she will have to fight Alex for Cristina's board seat and a freak accident causes two teenagers to be caught in a very compromising position.
In this Maggie centric episode, she continues to try to make a positive impression at the hospital but finds herself in extremely unfortunate situations. Meanwhile, Richard continues to hold onto his secret and the doctors work with a dying woman who is being kept alive by her daughter.
Owen introduces Callie to the Veterans Hospital patients in hopes that she will help them with her robotic limb lab, Jo becomes jealous of Alex and Meredith's friendship, and Maggie continues to confide in Richard. Meanwhile, Alex and Bailey prepare to go in front of the board.
Secrets from Ellis Grey's past come to light when Meredith watches old videos and reads through her mother's journals. Meanwhile, Maggie rocks the hospital with an unexpected announcement; Alex gets new responsibilities and Callie focuses her attention on the Veterans' project.
In this Callie and Arizona centric episode, the couple takes a look into the problems that have contributed to their troubled marriage. At work, Callie immerses herself in the Veterans' project, and Arizona struggles to impress Dr. Herman. Meanwhile, Richard leans on Bailey for advice.
Owen becomes invested in a patient when he realizes she may have served in the military, April's mother pays her daughter a visit and bonds with Jackson, and Derek plans a family dinner. Meanwhile, a patient's diagnosis causes Bailey to reconsider her own health issues and Dr. Herman drops a bombshell on Arizona.
Secrets about Amelia's past addictions come to light and cause problems for her at the hospital; Bailey oversees Jo's first solo surgery; and Arizona must make an executive decision in Dr. Herman's absence. Meanwhile the doctors spring into action when a couple arrives at the emergency room after escaping a fire.
Maggie and Meredith disagree with Derek about the best way to approach a patient's case, which leads to a bigger argument between the couple. Meanwhile, Callie feels responsible when one of her veterans is pushed too far and one doctor's routine procedure results in a devastating diagnosis, on the winter finale.
As Derek prepares for his move to DC, Meredith keeps herself busy at the hospital. Meanwhile, Jackson and April deal with difficult news, and Arizona and Amelia discuss how to best approach Dr. Herman.
April stays optimistic as Arizona begins testing on her baby; Dr. Herman plans out a crash course in fetal surgery; and Owen and Callie encourage each other to get back into the dating scene. Meanwhile, Meredith, Maggie and Bailey use the 3D printer to gain a better understanding of their patient’s tumor.
After several discussions with Dr. Herman, April and Jackson must face their situation head on and make a difficult decision regarding their unborn child. Catherine arrives in Seattle and bumps into Richard at the hospital. Meanwhile, Meredith tries to find someone to take care of the kids so she can visit Derek for the weekend, and Amelia shows Stephanie some tough love when they work together on a case.
Maggie gets upset when Meredith dodges her questions about DC; Bailey and Ben become concerned about Ben's brother after he is admitted to the hospital, and Dr. Herman starts to warm up to Arizona. Meanwhile, Richard feels manipulated by Catherine.
The hospital doctors become fascinated with Dr. Herman's case when Amelia gives a lecture detailing the intricacies of the surgery. Arizona and Herman continue to bond over the amount of cases they are trying to complete before the big surgery. Meanwhile, Bailey brings them a case of a pregnant woman who is close to her heart.
In this Amelia-centric episode, Amelia engages in the surgery of a lifetime as a crowd of doctors look on from the gallery. With Stephanie by her side, she begins operating on Dr. Herman, but quickly realizes it's far more difficult than she anticipated. Meanwhile, Bailey becomes skeptical when Arizona takes on one of Herman’s cases.
An earthquake shakes the ground at Grey Sloan Memorial Hospital, trapping Maggie in an elevator and threatening Meredith's long streak of successful surgeries. Meanwhile, Owen gives medical advice to a child over the phone and Ben confides in Jackson.
A patient's condition sparks a conversation between Richard and Maggie about Alzheimer's disease; April and Jackson struggle to return to their normal lives and Arizona is faced with the reality that Callie is moving on. Meanwhile, Meredith reveals her biggest fears about Derek.
A school field trip to the hospital takes a dramatic turn when the kids witness two injured cops enter the emergency room. Meanwhile, Stephanie sets her eyes on one of the chaperones, Callie operates on the leg of the police captain and Amelia must face her feelings for Owen.
Upon realizing that Owen and Amelia have been seeing each other behind her back, Meredith comes down hard on her sister-in-law causing Amelia to rethink things. Meanwhile, Catherine springs into action when a man is brought into the hospital after his wife seeks revenge on his cheatings ways.
A small plane crash in Seattle causes multiple casualties and brings back horrible memories for the doctors, especially Meredith and Arizona. Meanwhile, friction between Owen and Amelia makes for an uncomfortable working situation for Stephanie.
Ben worries that an innocent conversation with Derek could end up causing problems for Bailey; Cristina turns to Shane as tension with Meredith increases; April's upcoming wedding creates an uncomfortable situation for Stephanie and Jackson.
Couples panic when the hospital announces a nonfraternization policy; Owen and Emma discuss the future; Meredith and Cristina have some girl time; Richard asks the residents for help with a rare cancer case.
Arizona's bad day escalates when she advises a patient on a potential double amputation; Derek breaks a promise; Stephanie and Jo find an abandoned baby; the nonfraternization rule leads to a suspension.
Cristina enlists Meredith to help her prepare an acceptance speech for her possible Harper Avery win and while Owen offers to attend the ceremony with her, she insists on going alone. Meanwhile, Derek feels overwhelmed between his responsibilities at home and at the hospital. April and Jackson come to a disagreement on children and religion, and Callie and Arizona try to reconnect in their marriage.
Jackson is given the daunting task of delivering disappointing news to the doctors. Meanwhile, Derek's sister Amelia drops by for a surprise visit, Richard surprises Catherine in Boston and when Bailey gets frustrated by the slow pace of her research, she makes a risky decision.
Cristina looks to Meredith for advice as she assesses her future at the hospital. Derek and Amelia work together on a difficult surgery involving conjoined twins. Meanwhile, Jo is spread too thin when she tries to work on several cases at once and Stephanie realizes the truth about Bailey's bubble boy case.
With Derek away, Meredith spends time with Amelia and finds out her true feelings about her time in Seattle. Bailey deals with the ramifications of her actions and Callie receives devastating news. Meanwhile, the residents panic after hearing that one of them will be fired.
On the season ten finale, the doctors of Grey Sloan Memorial Hospital bid an emotional farewell to the beloved Cristina Yang. A possible act of terrorism rocks Seattle and causes chaos at the hospital. Meanwhile, Meredith makes a life changing decision and one doctor receives shocking news.
Bailey continues to shut everyone out; Owen worries that Ethan could end up in foster care; a new craniofacial specialist comes to the hospital to work on a young patient; a magician's assistant needs medical attention after a trick goes awry.