House

Eight weeks after the death of his girlfriend, Amber, Wilson is still mourning her death, and his relationship with his best friend House is shattered. Needing to make a change in his life and give himself time to recover emotionally, Wilson resigns from Princeton-Plainsboro. He is forced to decide if House is a destructive force in his life, while House has to determine if he's responsible for the death of his best friend's girlfriend. The team must push forward as they encounter a case involving an assistant to a high-profile executive, who is a textbook "Type A" personality. The team suspects that the patient's symptoms stem from her obsession to constantly please her demanding boss. However, her shocking medical condition forces the team to rethink their initial diagnoses and see the case through House's eyes. Meanwhile, Cuddy attempts to salvage the irreparable rift between House and Wilson, and Thirteen struggles to treat the patient objectively without bringing the reality of her own medical condition to the case.

When several people die suddenly and without warning five years after receiving transplants from a single organ donor, House and the team rush to save the only two surviving recipients. With one already dying and the other healthy but sure to fall ill at any moment, the team must find out what was wrong with the original organ donor. As the team sorts through the records on the deceased donor recipients to find the common thread, they must deal with a new intrusion. House has hired Lucas (guest star Michael Weston), a private investigator, to dig up information about the deceased despite the team's skepticism. Meanwhile, House auditions new best friends to replace Wilson, and soon uses Lucas for his own personal means to spy on Wilson and the other team members.

House and the team take on the case of a struggling artist (guest star Breckin Meyer) who has been painting bizarre portraits. His undiagnosed illness is distorting his perception, threatening to undermine his career, his relationships and everything else in his life. The team soon finds out that he hasn't sold anything lately and is on three separate drug trials to pay the bills. House must unlock the puzzle of which drugs are causing which symptoms before it's too late. Meanwhile, House continues to have private investigator Lucas Douglas (guest star Michael Weston) dig up dirt on everyone on his team, including Taub who is having trouble in his marriage.

When House receives word that his father has passed away, he brushes off the news and dismisses the idea of going to the funeral. However, he is soon coerced into going despite his strongest protests. Back at Princeton-Plainsboro, the team encounters the case of a young woman adopted by American parents who collapsed while in China looking for her birth parents. With House en route to his father's funeral, he must work with the team to diagnose the woman via cell phone while on the road. The team runs through possible diagnoses and various genetic disorders, but when House's phone dies, the team must decipher what House was trying to tell them before the girl's condition deteriorates. Meanwhile, the back story of how House and Wilson met for the first time is revealed.

When a woman with whom Thirteen had a one-night stand falls ill and has a seizure at Thirteen's apartment after a night of partying, Thirteen accompanies the woman to Princeton-Plainsboro where House and the team take on her case. House jumps on the opportunity to delve into Thirteen's personal life, and he and Foreman search Thirteen's apartment to find any possible causes of the woman's illness. Thirteen suspects the woman's drug use has caused her condition, but she soon finds the patient has a long medical history and has seen several doctors over the past few years. She soon finds out the patient slept with her only to get to Dr. House, and that she had been trying to get House to take her as a patient for over a year. Foreman sees evidence of Thirteen's hard-partying lifestyle and confronts her about her self-destruction, warning her that her attitude is sending her life and her job into a downward spiral. Meanwhile, House keeps his private investigator, Lucas (guest star Michael Weston), hot on Wilson's trail.

The team takes on the case of a dreary middle-aged man who has been experiencing unexplained recurring blackouts and time lapses. With possible diagnoses ranging from a stroke to a concussion to toxins from the consumer products he has been testing for work, they soon find that the man, who is raising his 12-year-old daughter on his own, has been experiencing intense sleepwalking spells. As the team tries to find out what he could be doing during his sleep to make himself sick, his condition continues to deteriorate and his daughter also falls gravely ill. Meanwhile, House finds out Cuddy is going to adopt a baby that is due in two weeks. But when Cuddy meets the birth mother in person and notices a strange rash on her arm, Cuddy brings the mother to Princeton-Plainsboro where her condition worsens. Cuddy must take on the case as both a doctor and a potential mother, and she and the team are faced with a heart-wrenching decision that could risk either the birth mother's or the baby's life.

When an agoraphobic man falls mysteriously ill and adamantly refuses to leave his home to get treatment at the hospital, House and the team go to him to figure out what might be wrong. Cameron takes charge as she has treated the patient before, and she and the team figure out ways to bring the hospital to the patient's home, much to Cuddy's disapproval. But as the patient's condition worsens and their options for treating him inside his home become increasingly limited, House and the team scheme to get the man into the hospital for surgery without causing any further physical trauma or emotional anxiety. Meanwhile, Cameron and Chase attempt to work through some kinks in their relationship, and House deals with an annoying itch he cannot seem to scratch as Wilson comes up with his own analogies about House's prickly situation.

The team takes on the case of a 16-year-old factory manager who fell ill when her lungs suddenly filled with fluid while at work. The teenager informs House and team that she is an emancipated minor living on her own and supporting herself, and has ever since her parents passed away. The team begins treatment for suspected heart problems, but when Kutner chooses to sympathize with the patient rather than follow House's directions, he and the team find out the hard way that the girl may not be telling them the truth. Meanwhile, Foreman asks for House's permission to work on a clinical trial and House rejects his proposal. In an effort to prove himself capable of working without House's supervision, Foreman takes on his own pediatric case. But when the unexplained illness brings the child to the brink of death, Foreman is left questioning his ability to work free from House's custody.

A gun-wielding man from the waiting room at the Princeton-Plainsboro clinic takes House, Thirteen and several patients from the waiting room hostage in Cuddy's office. The man claims to be sick with a long undiagnosed illness and demands medical attention from the best doctor in the hospital, threatening to kill any hostages necessary along the way. With a room full of already sick patients, House must use them as guinea pigs to assure the hostage-taker that the medications he is administering to him are legitimate. As Cuddy and the rest of House's team communicate with House over the phone to run tests and offer possible diagnoses, they ponder the possibility that the hostage-taker has nothing physically wrong with him and that everyone in Cuddy's office could wind up dead. With one hostage already shot, Thirteen wagers her own already diminished health as she simultaneously receives the experimental treatments the hostage is receiving. Her life lies in danger as House's own determination to diagnose the hostage-taker threatens to thwart the SWAT team's plan to put an end to the standoff.

House and the team take on the case of a high-profile fitness trainer who collapses while shooting an infomercial. As the team tests her for possible conditions such as exercise-induced asthma, steroid abuse or even a possible vitamin deficiency due to her strict diet, the patient's condition continues to worsen. Though she touts herself as an all-natural fitness guru, the team soon discovers she has a slimming secret that may be contributing to her deteriorating condition. Meanwhile, Thirteen begins her participation in a clinical drug trial for Huntington's disease led by Foreman, Kutner sets up and runs an online medical advice clinic under House's name and Cuddy moves into House's office while hers is being repaired, much to the dismay of her new officemate.

House and the team encounter a teenager who collapsed during her high school Christmas program. They soon find the troubled teen dealt with more than her share of bullying at school, and as her condition continues to deteriorate, the team must delve deeper to get to the bottom of her mysterious illness. Foreman continues to work with Thirteen on the Huntington's disease drug trial, and their relationship progresses when he learns a valuable lesson from her. House gives a clinic patient an unbelievable holiday gift and keeps the team guessing about who may have sent him a particularly thoughtful Christmas present. Meanwhile, Cuddy receives an unexpected gift of her own.

At Cameron's urging, House and the team take on the case of a man living with such severe chronic pain that he tries to kill himself, unable to go on after living for years without a diagnosis or any relief from his suffering. As they try to determine whether the man's pain is psychosomatic or caused by a physical disease, parallels between the patient and House's experiences with excruciating, prolonged pain become apparent. When the patient again attempts suicide under the team's care, their search for answers becomes urgent. Meanwhile, Foreman and Thirteen explore their now complicated relationship as they work together on the Huntington's disease clinical drug trial, and Cuddy finds that taking care of her newly adopted baby leaves her little time to run a hospital and baby-sit House at the same time.

Cuddy decides to spend more time at home to take care of her newly adopted baby and passes some of her day-to-day responsibilities off to Cameron, including supervising House. Cameron is forced to play House's games and becomes involved in a power struggle as he and the team take on the case of a Special Education teacher who collapsed after spitting up blood in the middle of class. As House tests Cameron's tolerance for his extreme measures, the patient continues to fall ill and House insists the teacher's seemingly inherent goodness is actually a pathology. Meanwhile, Foreman must make a critical decision regarding Thirteen's participation in the Huntington's drug trial.

100th Episode Milestone! House and the team take on the case of a woman who collapsed in the middle of a cooking class, and they soon learn she is a highly-renowned cancer researcher who recently gave up her entire career in order to pursue her own personal happiness. Though the team struggles to understand how the woman could give up saving lives for the sake of her own contentment, each grapple with the pursuit of happiness (or lack thereof) in their own lives. As the patient's condition continues to worsen, so does Thirteen's as she begins to suffer serious and life-threatening reactions to the experimental Huntington's Disease clinical trial. Meanwhile, Cuddy attempts to make House's life miserable for him in retaliation for his part in her own unhappiness.

When a priest who runs a homeless shelter sees a bleeding Jesus hovering at his doorstep, he is admitted to the ER. House takes on the case as a distraction for the team while he confronts Foreman and Thirteen about their relationship. The team soon learns the priest had been involved in a molestation scandal that caused him to lose his faith. However, just as they are about to dismiss his case, the patient's condition takes a drastic turn for the worse, and House grapples with his past and his belief.

The team encounters a teenage boy who collapsed from severe pelvic pain after playing basketball. Tests reveal the boy has genetic mosaicism, or both male and female DNA, and the boy's parents inform House and the team that the boy is unaware of his condition. They consciously chose a gender for him when he was born and raised him accordingly, never telling him about his unique condition. However, when his condition worsens and his life is threatened, the parents wonder whether they made the right decision. Meanwhile, Cuddy and Wilson suspect something is wrong with House when he starts acting way too nicely. When they discover the shocking answer, they must face the prospect that House may be changed forever.

House and the team take on the case of Nick (guest star Jay Karnes), a book editor who loses his inhibition and starts insulting coworkers at a dinner party one night before falling ill. The team realizes Nick has frontal lobe inhibition, which has caused him to lose his filter and vocalize all of his innermost thoughts, resulting in extremely insulting outbursts. As Nick's free speech lends to some amusing and insightful comments regarding the team, he must deal with the consequences of being unable to lie to his wife and everyone else important in his life. Meanwhile, House suspects Wilson and Taub are keeping something from him when he catches them both in a lie. House is determined to get to the bottom of it.

House and the team take on the case of Morgan (guest star Judy Greer) who works in a nursing home with a pet cat who only sleeps next to people if they are about to die - and does so with alarmingly accuracy. When it seems the cat has predicted her own death, Morgan, convinced she is about to die, fakes a seizure in order to get to House to have him diagnose her before it's too late. House dismisses her as a nut job, but is intrigued with the claim about the cat and sets out to disprove Morgan's theory. When she falls seriously ill, he and the team are forced to get to the bottom of her mysterious illness - as well as the mystery of the cat with the kiss-of-death. Meanwhile, Taub struggles with his finances and reconnects with an old high school friend at the clinic whose business successes present Taub with an entrepreneurial opportunity he had not previously considered.

We find ourselves inside the mind of Lee (guest star Mos Def) as he awakens after a bicycle accident in New York unable to move or communicate verbally. From his unique perspective, we hear Lee's inner thoughts as House, injured in a motorcycle accident, occupies the hospital bed next to him. House takes notice of Lee as his doctor writes him off as being brain-dead and begins to arrange his organ donations. However, House confirms that Lee is not brain dead at all, but rather has "locked-in" syndrome - he is completely conscious but unable to let anyone know. As House develops a system to communicate with Lee by having him blink once for "no" and twice for "yes," he is intrigued by the case and tries to figure out what is causing Lee's condition, much to the disdain of the presiding physician. When House gets Lee transferred to Princeton Plainsboro, the team is on the case to try to save Lee. As we learn more about Lee and his family, we also see House and the team through Lee's unique perspective, lending insight into their not-so-transparent relationships. When Lee loses his ability to blink and continues to fall ill, the team must race to find the key to unlock his condition. Meanwhile, Wilson suspects House is hiding something from him when he refuses to divulge why he was in New York when he got into his motorcycle accident.

Charlotte, an older woman who has spent the last six months taking care of her husband Eddie (guest star Meat Loaf), is rushed to Princeton Plainsboro for immediate treatment after collapsing from respiratory failure at Eddie's deathbed. With both in the hospital, the husband and wife team become a double mystery when Eddie's condition sporadically improves while Charlotte's condition is deteriorating. The urgency of Charlotte's medical condition breathes new life into their romantic relationship, and their regrets of what could have been are replaced with tenderness as Charlotte informs the team she wants Eddie to have her heart should she die before him. The team is forced to make a difficult choice as both of their lives are nearing an end.

Cameron postpones her vacation with Chase in order to ask House to accept the case of an environmental radical who collapsed at a protest with unexplainable symptoms. Although suspicious of her motives, House agrees. Since she pushed him to take the case so emphatically, House forces Cameron to take the lead and run many of the tests on the patient. Meanwhile, House is unsure of Wilson's new healthy diet.

The team takes on the case of a deaf 14-year-old named Seth who collapsed after he started "hearing" explosions while competing in a wrestling match. When the team tries to test him for seizures, Seth loses vision in one eye, complicating House's bunk theory of "Exploding Head Syndrome." As his condition worsens, the team has an ethical disagreement about the patient and his mother's adamant decision to forego cochlear implants to supplement his hearing. When the prospect of giving Seth the ability to hear for the first time in his life arises, House and the team are faced with a resounding decision. Meanwhile, House's lack of sleep starts to play tricks on his mind, but he finds his insomnia may be a gift instead of a burden.

House and the team take on the case of a ballerina (guest star Jamie Tisdale) whose lungs collapse in the middle of a performance. When the treatment causes her skin to fall off, the dancer faces not only the prospect of never dancing again but also of dying an agonizing death. The team must use their imaginations to carefully choreograph ways to test and treat her delicate body without killing her. Meanwhile, House continues to suffer from a severe lack of sleep and is still haunted by Amber (guest star Anne Dudek). While enlisting Wilson's help to diagnose himself, he is willing to do the unthinkable to make his visions stop.

House and the team are intrigued by Scott, a man whose left brain and right brain operate independently, leaving him with two distinct personalities and no control over some of his actions. As the two sides of Scott's brain struggle for dominance, his warring personalities make it increasingly difficult for the team to figure out what is causing the unique problem. The team is forced to use some unusual methods to get him to cooperate with their necessary testing. Meanwhile, when House refuses to make an appearance in the clinic, Cuddy takes an unconventional approach to force House to make up the time with a particular patient (guest star Carl Reiner).