Tommy Egan cuts all ties and puts New York in his rearview mirror for good when he arrives in Chicago and sets his sights on becoming the biggest drug dealer the Second City has ever seen. As Tommy starts making waves in the Chicago drug game, he attracts the attention of the city's biggest players and finds himself forging profitable alliances and deadly enemies. Tommy forms an uneasy relationship with CBI, one of Chicago's most formidable crews led by ex-convict Diamond Sampson, and comes into conflict with Walter Flynn, head of the Irish Mob, and his two children. Their paths all cross when a mysterious new designer drug hits the scene and Tommy realizes that whoever controls this drug, controls the city. But Tommy is unsure of who he can trust, especially when ghosts from his past unexpectedly turn up and turn Tommy's world upside down.