When Dr. Rhodes (Colin Donnell) and Dr. Downey (guest star Gregg Henry) treat a patient with a multitude of health and heart issues, they uncover he might be misdiagnosed and disagree over the best course of action. Dr. Choi (Brian Tee), riding along with paramedic Sylvie Brett (guest star Kara Killmer), responds to a call for a man with a leg injury, but complications arise in getting to him since the home is wrought with excessive hoarding. Meanwhile, treating a patient who was bitten by her own dog, Dr. Manning (Torrey DeVitto) and Sarah (Rachel DiPillo) have suspicions about the reason for the injury and what it might mean. Meanwhile, Goodwin (S. Epatha Merkerson) ensures that everyone is on their best behavior when the Joint Commission makes a surprise visit to Chicago Med to evaluate and rate the hospital's standards. Oliver Platt, Nick Gehlfuss, Yaya DaCosta and Marlyne Barrett also star.