Hotel Amazon chronicles longtime friends Rusty Johnson and Stephan Jablonski as they leave New York to pursue their dream of building a world-class resort in the middle of the Peruvian Amazon. Johnson and Jablonski discover that the Amazon is a fierce terrain, and building a luxury resort on top of it is a grueling endeavor. In order to reach their goals, Johnson and Jablowski need to overcome dire conditions, including harsh jungle weather, dangerous native creatures and a severe lack of essential supplies.