Alexander and Cesare are reconciled at last, and the Pope reveals that the Papal Armies have been strengthened and re-equipped with the money saved from the Crusade and the proceeds of the Jubilee. Now, the Borgias are ready to move against their enemies the Sforzas and are ready to take their first step towards their ultimate goal: to carve out a hereditary kingdom across the heart of Italy. Cesare marches his fearsome army to lay siege to Catherina Sforza's castle at Forli. Catherina is determined to resist despite the artillery bombardment and the danger of starvation in the bitter winter. Micheletto (Sean Harris) reappears from the shadows - his broken heart will not yet let him return to Cesare's service, but he does advise Cesare of weak spots in Forli's defences. Back in Rome, Cesare finds that Alfonso (Sebastian De Souza) has become even more aggressive and Cesare plans to murder him. But circumstances become deadly when a scuffle breas out between Cesare and a drunk Alfonso. The doctor reports that Alfonso will certainly die, slowly and painfully over several days. Devastated, Lucrezia turns to her potions to end his life painlessly with Cesare vowing that now she will be his for good.