This book constitutes the refereed proceedings of the 10th Conference on Artificial Intelligence in Medicine in Europe, AIME 2005, held in Aberdeen, UK in July 2005. The 35 revised full papers and 34 revised short papers presented together with 2 invited contributions were carefully reviewed and selected from 148 submissions. The papers are organized in topical sections on temporal representation and reasoning, decision support systems, clinical guidelines and protocols, ontology and terminology, case-based reasoning, signal interpretation, visual mining, computer vision and imaging, knowledge management, machine learning, knowledge discovery, and data mining.