Includes a basic understanding of the regulatory process and the means by which compliance can be assured; an understanding of the basic principles of controlling pain and distress, preventing intraoperative infection, and assuring a humane death in the animals used; and an awareness of the responsibilities one assumes when choosing to use lab. animals. Contents: regulations and requirements; alternative methodologies; animal care and use; principles of anesthesia, analgesia, and aseptic technique; perioperative care; euthanasia; organizations, associations, and societies; and references.