Bernice Rubens was born in Cardiff, Wales in July 1928. She read English at the University of Wales and married young; she worked as an English teacher and a filmmaker before she began writing at the age of 35, when her children started nursery school. Reubens's first novel, Set on Edge (1960), was threaded with the themes of Orthodox Judaism and family life. The book was a success, which encouraged her to continue with writing: her second novel, Madame Sousatzka (1962), was filmed by John Schlesinger, with Shirley MacLaine in the leading role, in 1988, and her fourth novel, The Elected Member, won the 1970 Booker prize. She was shortlisted for the same prize again in 1978 for A Five Year Sentence.
Reubens was an honorary vice-president of International PEN and served as a Booker judge in 1986; her last novel, The Sergeants' Tale, was published in 2003, a year before her death at age 76.