• Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation
• Uses a concise and easy-to-read style, with many illustrated examples
• Updates material, examples, and references from the first edition
• Adds coverage of organocatalysts and organometallic reagents
This book is composed of 33 chapters. The first chapters focus on the synthesis of biologically active natural compounds, including metabolites of arachidonic acid, erythromycin A, verrucarins, steroids, anthracyclines, terpenes, yeast alanine t-RNA, beta-lactam antibiotics, and palitoxin. Other chapters deal with the central problems in stereoselective and chiral synthesis, as well as processes of high degree of stereochemical control and asymmetric induction. These chapters also describe chiral pool synthesis by means of carbohydrate precursors. This book also examines the methodologies in organic synthesis using reagents with boron, aluminum, transition metals, silicon, phosphorus, and sulfur. The remaining chapters are devoted to reactions involving radical initiated ring closure, small ring hydrogenolysis, annulene synthesis, vicarious nucleophilic substitution of aromatic hydrogen, and dichlorine monoxide mediated powerful chlorination.
This book is of value to organic chemists and allied scientists.
* Provides students with the organic chemistry background required to succeed in advanced courses.
* Practice problems included at the end of each chapter.
From the contents:
* Amino Acid, Peptid and Protein Receptors
* Carbohydrate Receptors
* Ammonium, Amidinium and Guanidinium Receptors
* Anion Receptors
* Molecular Capsules and Self Assembly
* Dynamic Combinatorial Libraries based on Molecular Recognition
* Molecular Machines
Aimed at graduate students and specialists in the field, this is also of interest to pharmaceutical companies involved in drug design, as well as chemical companies with a polymer or nanotechnology group. In addition, analytical companies working on the advanced equipment covered here will find stimulating new applications.
A series of advanced treatises founded by Professor Saul Patai and under the general editorship of Professor Zvi Rappoport
The Patai Series publishes comprehensive reviews on all aspects of specific functional groups. Each volume contains outstanding surveys on theoretical and computational aspects, NMR, MS, other spectroscopical methods and analytical chemistry, structural aspects, thermochemistry, photochemistry, synthetic approaches and strategies, synthetic uses and applications in chemical and pharmaceutical industries, biological, biochemical and environmental aspects.
To date, over 100 volumes have been published in the series.
Recently Published Titles
* The chemistry of the Cyclopropyl Group (Volume 2)
* The chemistry of the Hydrazo Azo and Azozy Groups (Volume 2, 2 parts)
* The chemistry of Double-Bonded Functional Groups (Volume 3, 2 parts)
* The chemistry of Organophosphorus Compounds (Volume 4)
* The chemistry of Halides, Pseudo-Halides and Azides (Volume 2, 2 parts)
* The chemistry of the Amino, Nitro and Nitroso Groups (2 volumes, 2 parts)
* The chemistry of Dienes and Polyenes (2 volumes)
* The chemistry of Organic Derivatives of Gold and Silver
* The chemistry of Organic Silicon Compounds (2 volumes, 4 parts)
* The chemistry of Organic Germanium, Tin and Lead Compounds (Volume 2, 2 parts)
* The chemistry of Phenols (2 parts)
* The chemistry of Organolithium Compounds (2 parts)
* The chemistry of Cyclobutanes (2 parts)
* Forthcoming Titles
* The chemistry of Peroxides (Volume 2, 2 parts)
* The chemistry of Organozinc Compounds
* The chemistry of Anilines
The Patai Series Online
The Patai Series is available in electronic format on Wiley InterScience. All new titles will be published online and a growing list of older titles is added every year. It is the ultimate goal that all titles published in the Patai Series will be available in electronic format.