RU 486 Die Abtreibungspille: Medizinische und ethische Fragen

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In der Debatte um RU 486, die "Abtreibungspille", stehen oft weniger medizinische als vielmehr politische oder weltanschauliche Gesichtspunkte im Mittelpunkt. Dies weiß auch Etienne-Emile Baulieu, der den Wirkstoff entdeckt hat. Er weicht der moralischen Diskussion um die Abtreibung nicht aus, doch im Mittelpunkt seines Buches stehen die Etappen der Hormonforschung, die schließlich zur Entwicklung von RU 486 geführt haben. Leicht nachvollziehbar wird erklärt, welchen Einfluß die Hormone auf die Entstehung der Schwangerschaft haben und warum RU 486 zum Schwangerschaftsabbruch führt. Die medizinischen Erfahrungen mit dem Präparat, u.a. aus Frankreich, England und China, werden ausführlich geschildert. Die deutsche Diskussion über RU 486 faßt Prof. Lauritzen in einem Nachwort zusammen.
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Published on
Mar 8, 2013
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Health & Fitness / General
Medical / General
Medical / Gynecology & Obstetrics
Reference / General
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Advances in basic biological research have proceeded rapidly in recent years. The fields of molecular genetics and immunology have experienced dramatic breakthroughs, capturing the imagination of both the scientific community and the general public. With less public notice, receptor biology has brought a cascade of new discoveries and insights. The entire science of pharmacology has been virtually rewritten in terms of receptor phenomenology. In particular, the discovery of specific receptors for steroid and protein hormones has been of seminal importance. With this new information, we have advanced our understanding of the mechanism and specifity of hormone action. We can now explain how hormones interact selectively with specific target cells and how hormones alter biochemical events within the target cells. These facts have already impacted on applied problems of clinical medicine, particularly in diagnosis and treatment of cancer and some metabolic diseases. Now, a new and important application of basic receptor biology and chemistry looms ahead. Within a few short years since the discovery of the progesterone receptor, chemists have synthesized molecules with a greater affinity for the receptor than progesterone itself and which, while occupying the receptor, fail to trigger the events which transform a target cell from the unstimulated to the stimulated state. This is the basis of the competitive inhibitory action of the anti-progestational agent, synthesized by the chemists at Roussel Uc1af, Paris, and designated RU 486.
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