Evaluation of Sixteen Antimotion Sickness Drugs Under Controlled Laboratory Conditions

Charles D. Wood · Ashton Graybiel

Jan 1968 · U.S. Naval Aerospace Medical Institute, Naval Aerospace Medical Center

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The effectiveness of a drug in reducing susceptibility to acute motion sickness is readily determined in a slow rotation room (SRR) where the stressful Coriolis accelerations are under quantitative control and the experimenter and subject can collaborate under laboratory conditions. Fifty subjects were used, each serving as his own control, in evaluating 16 representative antimotion sickness drugs. Only the drugs with a sympathomimetic or parasympatholytic action and some of the antihistamines were notably effective. The summation effect of dextroamphetamine sulfate and 1-scopolamine hydrobromide provided far better protection than any single drug. Other classes of drugs had either a slightly favorable or slightly unfavorable action. (Author).