Beginning with simple theoretical models and experimental techniques, the book develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments.
Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. This updated version includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced.
The book is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or wish to understand the latest developments in this field.
Dr. Cavanagh is the William Neal Reynolds Distinguished Professor of Biochemistry at North Carolina State University. He is an expert in protein structural biology, particularly in how bacteria are able to protect themselves. Dr. Cavanagh received his Ph.D. in Chemistry/NMR spectroscopy from the University of Cambridge in 1988. He has held positions as a Senior Research Associate at The Scripps Research Institute, Director of Structural Biology at the Wadsworth Center (New York State Department of Health), Associate Professor of Biomedical Sciences (SUNY) and Professor of Chemistry (Purdue). Since 2000 he has been Professor of Biochemistry in the Department of Molecular & Structural Biochemistry at North Carolina State University. Dr. Cavanagh has served on numerous NIH and NSF grant review panels and is currently a permanent member of the MSFB Study Section at NIH . He has authored over 100 peer-reviewed research publications and has been awarded the Foulerton Gift & Binmore Kenner Fellowship of the Royal Society (1990), the Fullsome Award (1996), the NC State University Alumni Associations Outstanding Research Award (2005) and Entrepreneur of the Year- NC State University (2012). He runs the Jimmy V-NCSU Cancer Therapeutics Training Program, was Assistant Vice Chancellor for Research at NC State from 2012-2014 and is the co-founder and Chief Scientific Officer of Agile Sciences Inc., a Raleigh based biotechnology company focusing on antibiotic resistance.
Reviews of the First Edition
“For anyone wishing to know what really goes on in theirNMR experiments, I would highly recommend this book” –Chemistry World
“…I warmly recommend for budding NMRspectroscopists, or others who wish to deepen their understandingof elementary NMR theory or theoretical tools” –Magnetic Resonance in Chemistry
The book assumes only a basic knowledge of complex numbers andmatrices, and provides the reader with numerous worked examples andexercises to encourage understanding. With the explicit aim ofcarefully developing the subject from the beginning, the textstarts with coverage of quarks and nucleons and progresses throughto a detailed explanation of several important NMR experiments,including NMR imaging, COSY, NOESY and TROSY.
Completely revised and updated, the Second Edition features newmaterial on the properties and distributions of isotopes, chemicalshift anisotropy and quadrupolar interactions, Pake patterns, spinechoes, slice selection in NMR imaging, and a complete new chapteron the NMR spectroscopy of quadrupolar nuclei. New appendices havebeen included on Euler angles, and coherence selection by fieldgradients. As in the first edition, all material is heavilysupported by graphics, much of which is new to thisedition.
Written for undergraduates and postgraduate students taking afirst course in NMR spectroscopy and for those needing anup-to-date account of the subject, this multi-disciplinary bookwill appeal to chemical, physical, material, life, medical, earthand environmental scientists. The detailed physical insights willalso make the book of interest for experienced spectroscopists andNMR researchers.
• An accessible and carefully written introduction,designed to help students to fully understand this complex anddynamic subject
• Takes a multi-disciplinary approach, focusing on basicprinciples and concepts rather than the more practical aspects
• Presents a strong pedagogical approach throughout, withemphasis placed on individual spins to aid understanding
• Includes numerous worked examples, problems, furtherreading and additional notes
Praise from the reviews of the First Edition:
"This is an excellent book... that many teachers of NMRspectroscopy will cherish... It deserves to be a‘classic’ among NMR spectroscopy texts." NMRIN BIOMEDICINE
"I strongly recommend this book to everyone…it isprobably the best modern comprehensive description of thesubject." ANGEWANDTE CHEMIE, INTERNATIONAL EDITION