1817年徐畢克斯奉巴伐利亞國王麥希米連一世之命前往巴西探勘亞馬遜森林,當時德國科學家洪堡德(Alexander von Humboldt)雖然已經前往南美洲探勘,但區域僅限於西班牙殖民地,多半未觸及巴西,科學界對亞馬遜森林仍然相當陌生。因此,動物學家徐畢克斯與植物學家馬荻仕,兩人不畏艱苦、歷險無數,由南至北深入探勘了大部分亞馬遜流域區域,所採集的動植物標本近萬種,並發現大量新種。針對這趟旅程所寫的《巴西探勘之旅》,至今仍為研究巴西的重要文獻,達爾文的書房亦擺有這套旅記,足見徐畢克斯對後世學者的莫大鼓舞與影響。
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